| pubmed-article:12651943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0166417 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0015663 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0872184 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0017715 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12651943 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12651943 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12651943 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12651943 | pubmed:abstractText | The liver plays several critical roles in the metabolic adaptation to fasting. We have shown previously that the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is induced in fasted or diabetic liver and activates the entire program of gluconeogenesis. PGC-1alpha interacts with several nuclear receptors known to bind gluconeogenic promoters including the glucocorticoid receptor, hepatocyte nuclear factor 4alpha (HNF4alpha), and the peroxisome proliferator-activated receptors. However, the genetic requirement for any of these interactions has not been determined. Using hepatocytes from mice lacking HNF4alpha in the liver, we show here that PGC-1alpha completely loses its ability to activate key genes of gluconeogenesis such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase when HNF4alpha is absent. It is also shown that PGC-1alpha can induce genes of beta-oxidation and ketogenesis in hepatocytes, but these effects do not require HNF4alpha. Analysis of the glucose-6-phosphatase promoter indicates a key role for HNF4alpha-binding sites that function robustly only when HNF4alpha is coactivated by PGC-1alpha. These data illustrate the involvement of PGC-1alpha in several aspects of the hepatic fasting response and show that HNF4alpha is a critical component of PGC-1alpha-mediated gluconeogenesis. | lld:pubmed |
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| pubmed-article:12651943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12651943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651943 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12651943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12651943 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12651943 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:SpiegelmanBru... | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:PuigserverPer... | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:GonzalezFrank... | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:InoueYusukeY | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:RheeJamesJ | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:YoonJ CliffJC | lld:pubmed |
| pubmed-article:12651943 | pubmed:author | pubmed-author:FanMelinaM | lld:pubmed |
| pubmed-article:12651943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12651943 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12651943 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12651943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12651943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12651943 | pubmed:pagination | 4012-7 | lld:pubmed |
| pubmed-article:12651943 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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