| pubmed-article:12651207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12651207 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:12651207 | lifeskim:mentions | umls-concept:C0278704 | lld:lifeskim |
| pubmed-article:12651207 | lifeskim:mentions | umls-concept:C0001758 | lld:lifeskim |
| pubmed-article:12651207 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12651207 | pubmed:dateCreated | 2003-3-24 | lld:pubmed |
| pubmed-article:12651207 | pubmed:abstractText | The aim of this study was to determine therapy-related risk factors for the development of second malignant neoplasm (SMN) after childhood cancer. The German Childhood Cancer Registry (GCCR) registers all childhood malignancies since 1980 including SMN. A nested case-control study with 238 SMN cases and 450 controls was conducted. A confirmatory, as well as an explorative, analysis was performed. Radiotherapy showed a small effect on the risk of SMN for doses >or=65 Gy. Regarding the chemotherapeutical agents, we saw increased Odds Ratios (OR) for high doses of cyclophosphamide (CP >8000 mg/m(2) OR=6.3 (95% Confidence Interval (CI): 1.3-30.2)), cisplatinum (DDP >435 mg/m(2) OR=2.8 (95% CI: 1.1-6.7)) and mercaptopurine (MP >5000 mg/m(2) OR=4.5 (95% CI: 1.1-18.9)). Patients jointly receiving high doses of MP (>5000 mg/m(2)) and dexamethasone (DEXA >or=1200 mg/m(2)) had an OR=6.9 (95% CI: 1.2-40.3). Our results could be added to those of other investigations to give indications for modifying future therapeutic strategies for childhood cancer. | lld:pubmed |
| pubmed-article:12651207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12651207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12651207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12651207 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12651207 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:KleinGG | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:RitterJJ | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:EggertDD | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:MichaelisJJ | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:KaatschPP | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:SpixCC | lld:pubmed |
| pubmed-article:12651207 | pubmed:author | pubmed-author:WibbingRR | lld:pubmed |
| pubmed-article:12651207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12651207 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:12651207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12651207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12651207 | pubmed:pagination | 808-17 | lld:pubmed |
| pubmed-article:12651207 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
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| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:meshHeading | pubmed-meshheading:12651207... | lld:pubmed |
| pubmed-article:12651207 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12651207 | pubmed:articleTitle | Second malignant neoplasms after treatment of childhood cancer. | lld:pubmed |
| pubmed-article:12651207 | pubmed:affiliation | German Childhood Cancer Registry, Institute for Medical Biometrics, Epidemiology and Informatics, University Mainz, Germany. | lld:pubmed |
| pubmed-article:12651207 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12651207 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12651207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12651207 | lld:pubmed |
