| pubmed-article:12646630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12646630 | lifeskim:mentions | umls-concept:C0004359 | lld:lifeskim |
| pubmed-article:12646630 | lifeskim:mentions | umls-concept:C1540056 | lld:lifeskim |
| pubmed-article:12646630 | lifeskim:mentions | umls-concept:C1819447 | lld:lifeskim |
| pubmed-article:12646630 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12646630 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12646630 | pubmed:dateCreated | 2003-3-20 | lld:pubmed |
| pubmed-article:12646630 | pubmed:abstractText | An autoantibody against SS-A/Ro52 (Ro52) is most frequently found in the sera of patients with Sjögren's syndrome, systemic lupus erythematosus, and congenital heart block from anti-Ro52 Ab-positive mother. However, the physiological function of the autoantigen SS-A/Ro52 has not yet been elucidated. In this study, we describe the role of Ro52 protein in T cell activation. Overexpression of SS-A/Ro52 in Jurkat T cell resulted in enhanced IL-2 production following CD28 stimulation. Furthermore, transfection of anti-Ro52-specific small RNA duplexes partially blocked the expression of native and overexpressed Ro52 in Jurkat T cell, resulting in decreased IL-2 production via CD28 pathway in these cells. Finally, intracellular localization of Ro52 dramatically changed following CD28 stimulation. Our data reveal a novel function of Ro52 in CD28-mediated pathway, which eventually contributes to cytokine production and expression of the T cell biological programs. | lld:pubmed |
| pubmed-article:12646630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12646630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12646630 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12646630 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:YamochiTadano... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:MorimotoChika... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:TanakaHirotos... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:IwataSatoshiS | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:OhnumaKeiK | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:DangNam HNH | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:IshiiTomonori... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:UchiyamaMasah... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:MurakamiAkika... | lld:pubmed |
| pubmed-article:12646630 | pubmed:author | pubmed-author:TakasawaNaruh... | lld:pubmed |
| pubmed-article:12646630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12646630 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12646630 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:12646630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12646630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12646630 | pubmed:pagination | 3653-61 | lld:pubmed |
| pubmed-article:12646630 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12646630 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12646630 | pubmed:articleTitle | SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production. | lld:pubmed |
| pubmed-article:12646630 | pubmed:affiliation | Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:12646630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12646630 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12646630 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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