| pubmed-article:12644904 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C0006668 | lld:lifeskim |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C0002792 | lld:lifeskim |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12644904 | lifeskim:mentions | umls-concept:C0082514 | lld:lifeskim |
| pubmed-article:12644904 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12644904 | pubmed:dateCreated | 2003-3-19 | lld:pubmed |
| pubmed-article:12644904 | pubmed:abstractText | Previous investigations have indicated that the pharmacological effects of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with stimulation of calcitonin gene-related peptide (CGRP) release and CGRP prevents cardiac anaphylactic injury. In the present study, the protective effects of evodiamine on cardiac anaphylaxis were examined. Presensitized guinea-pig hearts challenged with specific antigen (bovine serum albumin) caused a marked decrease in coronary flow, left ventricular pressure and its derivatives (+/-dp/dt(max)), an increase in heart rate, and prolongation of P-R interval. Evodiamine (0.3 microM or 1 microM) markedly increased the content of CGRP in the coronary effluent concomitantly with a significant improvement of cardiac function and alleviation of the extension of P-R interval. Evodiamine at the concentration of 1 microM also inhibited the sinus tachycardia. The protective effect of evodiamine on cardiac anaphylaxis was abolished by CGRP(8-37), the selective CGRP receptor antagonist. These results suggest that evodiamine possesses a protective effect of cardiac anaphylactic injury and that the effect of evodiamine is related to stimulation of CGRP release. | lld:pubmed |
| pubmed-article:12644904 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12644904 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644904 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12644904 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12644904 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:YeFengF | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:DengHan-WuHW | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:LiYuan-JianYJ | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:HuChang-PingC... | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:TanGui-ShanGS | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:DuYan-HuaYH | lld:pubmed |
| pubmed-article:12644904 | pubmed:author | pubmed-author:RangWei-QingW... | lld:pubmed |
| pubmed-article:12644904 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12644904 | pubmed:volume | 367 | lld:pubmed |
| pubmed-article:12644904 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12644904 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12644904 | pubmed:pagination | 306-11 | lld:pubmed |
| pubmed-article:12644904 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12644904 | pubmed:meshHeading | pubmed-meshheading:12644904... | lld:pubmed |
| pubmed-article:12644904 | pubmed:meshHeading | pubmed-meshheading:12644904... | lld:pubmed |
| pubmed-article:12644904 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12644904 | pubmed:articleTitle | Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis. | lld:pubmed |
| pubmed-article:12644904 | pubmed:affiliation | Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Xiang-Ya Road 88, 410078 Changsha, Hunan, P.R. China. | lld:pubmed |
| pubmed-article:12644904 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12644904 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12644904 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12644904 | lld:pubmed |
