| pubmed-article:12644289 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0028633 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0042444 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0050079 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0013786 | lld:lifeskim |
| pubmed-article:12644289 | lifeskim:mentions | umls-concept:C0348005 | lld:lifeskim |
| pubmed-article:12644289 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12644289 | pubmed:dateCreated | 2003-3-19 | lld:pubmed |
| pubmed-article:12644289 | pubmed:abstractText | Electrical brain stimulation may be a therapeutic alternative for irreversible lesions in treatment-resistant patients with obsessive-compulsive disorder (OCD). We compared the effects of electrical stimulation and lesion in the nucleus accumbens (n acc) on the behaviour of rats in a model for OCD. Rats were tested for spontaneous alternation behaviour (AB) in a T-maze and assigned to four groups: an electrode implant group with stimulation 'ON' (stimON) or 'OFF' (stimOFF), a lesion or a sham group. Postoperatively, the number of arm visits and AB were tested after 8-hydroxy-2-(di-n-propylamino)-tetralin hydrobromide (8-OH-DPAT; 2 mg/kg) or saline administration. After 8-OH-DPAT administration, more arm visits were counted in the stimON (92.2%) and lesion groups (79.3%) than in both control groups (stimOFF 54.2; sham 61.2%). AB was significantly decreased in the stimON (10.5%) and lesion groups (10.2%) relative to the sham (22.0%) but not to the stimOFF group (14.7%). After saline administration, rats performed more arm visits in the stimON (81.5% non-significant) and lesion groups (93.6% significant) relative to the stimOFF (70.8%) and the sham groups (74.5%). No significant differences, however, were observed for AB. In conclusion, both treatments resulted in a decreased AB after 8-OH-DPAT administration (modelling an increase in compulsions) and more arm visits. | lld:pubmed |
| pubmed-article:12644289 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12644289 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644289 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12644289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12644289 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12644289 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12644289 | pubmed:issn | 0166-4328 | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:RothR GRG | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:FeysHildeH | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:BogaertsKrisK | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:NuttinBartB | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:Demeulemeeste... | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:DewilMaartenM | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:TousseynThoma... | lld:pubmed |
| pubmed-article:12644289 | pubmed:author | pubmed-author:GybelsJanJ | lld:pubmed |
| pubmed-article:12644289 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12644289 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:12644289 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:12644289 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12644289 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12644289 | pubmed:pagination | 165-73 | lld:pubmed |
| pubmed-article:12644289 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:meshHeading | pubmed-meshheading:12644289... | lld:pubmed |
| pubmed-article:12644289 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12644289 | pubmed:articleTitle | Effects of electrical stimulation or lesion in nucleus accumbens on the behaviour of rats in a T-maze after administration of 8-OH-DPAT or vehicle. | lld:pubmed |
| pubmed-article:12644289 | pubmed:affiliation | Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neuroscience and Psychiatry, K.U. Leuven Provisorium 1, Minderbroedersstraat 17, Belgium. | lld:pubmed |
| pubmed-article:12644289 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12644289 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12644289 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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