| pubmed-article:12634389 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12634389 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:12634389 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12634389 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:12634389 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12634389 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12634389 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12634389 | pubmed:dateCreated | 2003-3-13 | lld:pubmed |
| pubmed-article:12634389 | pubmed:abstractText | It has been shown previously (S. Wadd, H. Bryant, O. Filhol, J. E. Scott, T.-T. Hsieh, R. D. Everett, and J. B. Clements, J. Biol. Chem. 274:28991-28998, 2000) that ICP27, an essential and multifunctional herpes simplex virus type 1 (HSV-1) protein, interacts with CK2 and with heterogeneous ribonucleoprotein K (hnRNP K). CK2 is a pleiotropic and ubiquitous protein kinase, and the tetrameric holoenzyme consists of two catalytic alpha or alpha' subunits and two regulatory beta subunits. We show here that HSV-1 infection stimulates CK2 activity. CK2 stimulation occurs at early times after infection and correlates with redistribution of the holoenzyme from the nucleus to the cytoplasm. Both CK2 stimulation and redistribution require expression and cytoplasmic accumulation of ICP27. In HSV-1-infected cells, CK2 phosphorylates ICP27 and affects its cytoplasmic accumulation while it also phosphorylates hnRNP K, which is not ordinarily phosphorylated by this kinase, suggesting an alteration of hnRNP K activities. This is the first example of CK2 stimulation by a viral protein in vivo, and we propose that it might facilitate the HSV-1 lytic cycle by, for example, regulating trafficking of ICP27 protein and/or viral RNAs. | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12634389 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12634389 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12634389 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12634389 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12634389 | pubmed:author | pubmed-author:ClementsJ... | lld:pubmed |
| pubmed-article:12634389 | pubmed:author | pubmed-author:RiceStephen... | lld:pubmed |
| pubmed-article:12634389 | pubmed:author | pubmed-author:KoffaMaria... | lld:pubmed |
| pubmed-article:12634389 | pubmed:author | pubmed-author:ZachosGeorgeG | lld:pubmed |
| pubmed-article:12634389 | pubmed:author | pubmed-author:KeanJoyJ | lld:pubmed |
| pubmed-article:12634389 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12634389 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:12634389 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12634389 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12634389 | pubmed:pagination | 4315-25 | lld:pubmed |
| pubmed-article:12634389 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
| pubmed-article:12634389 | pubmed:meshHeading | pubmed-meshheading:12634389... | lld:pubmed |
