| pubmed-article:12633880 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0751383 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C1337112 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:12633880 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:12633880 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:12633880 | pubmed:dateCreated | 2003-3-13 | lld:pubmed |
| pubmed-article:12633880 | pubmed:abstractText | Infantile and juvenile neuronal ceroid lipofuscinosis (NCLs) are progressive neurodegenerative disorders of childhood with distinct ages of clinical onset, but with a similar pathological outcome. Infantile and juvenile NCL are inherited in an autosomal recessive manner due to mutations in the CLN1 and CLN3 genes, respectively. Recently developed Cln1- and Cln3-knockout mouse models share similarities in pathology with the respective human disease. Using oligonucleotide arrays we identified reproducible changes in gene expression in the brains of both 10-week-old Cln1- and Cln3-knockout mice as compared to wild-type controls, and confirmed changes in levels of several of the cognate proteins by immunoblotting. Despite the similarities in pathology, the two mutations affect the expression of different, non-overlapping sets of genes. The possible significance of these changes and the pathological mechanisms underlying NCL diseases are discussed. | lld:pubmed |
| pubmed-article:12633880 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12633880 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12633880 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12633880 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12633880 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:Chattopadhyay... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:BrooksAndrew... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:PearceDavid... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:CurranTimothy... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:ElshatoryYass... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:HofmannSandra... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:GuptaPraveena... | lld:pubmed |
| pubmed-article:12633880 | pubmed:author | pubmed-author:RamalingamVij... | lld:pubmed |
| pubmed-article:12633880 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12633880 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:12633880 | pubmed:volume | 538 | lld:pubmed |
| pubmed-article:12633880 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12633880 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12633880 | pubmed:pagination | 207-12 | lld:pubmed |
| pubmed-article:12633880 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:meshHeading | pubmed-meshheading:12633880... | lld:pubmed |
| pubmed-article:12633880 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12633880 | pubmed:articleTitle | Early changes in gene expression in two models of Batten disease. | lld:pubmed |
| pubmed-article:12633880 | pubmed:affiliation | Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. | lld:pubmed |
| pubmed-article:12633880 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12633880 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12633880 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12752 | entrezgene:pubmed | pubmed-article:12633880 | lld:entrezgene |
| entrez-gene:19063 | entrezgene:pubmed | pubmed-article:12633880 | lld:entrezgene |
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