| pubmed-article:12626740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0086413 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0020966 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12626740 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:12626740 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12626740 | pubmed:dateCreated | 2003-3-19 | lld:pubmed |
| pubmed-article:12626740 | pubmed:abstractText | Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation. | lld:pubmed |
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| pubmed-article:12626740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12626740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12626740 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12626740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12626740 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12626740 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12626740 | pubmed:author | pubmed-author:WaldmannThoma... | lld:pubmed |
| pubmed-article:12626740 | pubmed:author | pubmed-author:BerzofskyJay... | lld:pubmed |
| pubmed-article:12626740 | pubmed:author | pubmed-author:OhSangKonS | lld:pubmed |
| pubmed-article:12626740 | pubmed:author | pubmed-author:BurkeDonald... | lld:pubmed |
| pubmed-article:12626740 | pubmed:author | pubmed-author:PereraLiyanag... | lld:pubmed |
| pubmed-article:12626740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12626740 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:12626740 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12626740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12626740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12626740 | pubmed:pagination | 3392-7 | lld:pubmed |
| pubmed-article:12626740 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12626740 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12626740 | pubmed:articleTitle | Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. | lld:pubmed |
| pubmed-article:12626740 | pubmed:affiliation | Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:12626740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12626740 | pubmed:publicationType | In Vitro | lld:pubmed |
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