Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis.

Source:http://linkedlifedata.com/resource/pubmed/id/12623848

Blood 2003 Jul 1 102 1 276-83

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PMID
12623848