Linked Life Data

12621122

Source:http://linkedlifedata.com/resource/pubmed/id/12621122

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pubmed-article:12621122pubmed:dateCreated2003-4-18lld:pubmed
pubmed-article:12621122pubmed:abstractTextPerinatal brain damage is associated not only with hypoxic-ischemic insults but also with intrauterine inflammation. A combination of antenatal inflammation and asphyxia increases the risk of cerebral palsy >70 times. The aim of the present study was to determine the effect of intracisternal (i.c.) administration of endotoxin [lipopolysaccharides (LPS)] on subsequent hypoxic-ischemic brain damage in neonatal rats. Seven-day-old Wistar rats were subjected to i.c. application of NaCl or LPS (5 microg/pup). One hour later, the left common carotid artery was exposed through a midline neck incision and ligated with 6-0 surgical silk. After another hour of recovery, the pups were subjected to a hypoxic gas mixture (8% oxygen/92% nitrogen) for 60 min. The animals were randomized to four experimental groups: 1) sham control group, left common carotid artery exposed but not ligated (n = 5); 2) LPS group, subjected to i.c. application of LPS (n = 7); 3) hypoxic-ischemic study group, i.c. injection of NaCl and exposure to hypoxia after ligation of the left carotid artery (n = 17); or 4) hypoxic-ischemic/LPS study group, i.c. injection of LPS and exposure to hypoxia after ligation of the left carotid artery (n = 19). Seven days later, neonatal brains were assessed for neuronal cell damage. In a second set of experiments, rat pups received an i.c. injection of LPS (5 microg/pup) and were evaluated for tumor necrosis factor-alpha expression by immunohistochemistry. Neuronal cell damage could not be observed in the sham control or in the LPS group. In the hypoxic-ischemic/LPS group, neuronal injury in the cerebral cortex was significantly higher than in animals that were subjected to hypoxia/ischemia after i.c. application of NaCl. Injecting LPS intracisternally caused a marked expression of tumor necrosis factor-alpha in the leptomeninges. Applying LPS intracisternally sensitizes the immature rat brain to a subsequent hypoxic-ischemic insult.lld:pubmed
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pubmed-article:12621122pubmed:volume53lld:pubmed
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pubmed-article:12621122pubmed:pagination770-5lld:pubmed
pubmed-article:12621122pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12621122pubmed:year2003lld:pubmed
pubmed-article:12621122pubmed:articleTitleIntracisternal application of endotoxin enhances the susceptibility to subsequent hypoxic-ischemic brain damage in neonatal rats.lld:pubmed
pubmed-article:12621122pubmed:affiliationDepartment of Obstetrics and Gynecology, University Hospital Maastricht, The Netherlands.lld:pubmed
pubmed-article:12621122pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12621122pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed