| pubmed-article:12620067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C1533698 | lld:lifeskim |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:12620067 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12620067 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12620067 | pubmed:dateCreated | 2003-3-6 | lld:pubmed |
| pubmed-article:12620067 | pubmed:abstractText | The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4'-aminospiro[piperidine-4,2'(1'H)-quinazolin]-4'-amines is described. Members of both series exhibit nanomolar potency and high selectivity for the inducible isoform of the enzyme (i-NOS) relative to the constitutive isoforms in vitro. Efficacy in acute and chronic animal models of inflammatory disease following oral administration has also been demonstrated using these compounds. | lld:pubmed |
| pubmed-article:12620067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12620067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12620067 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12620067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12620067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12620067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12620067 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12620067 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:WallaceAlan... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:TinkerAlan... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:BeatonHaydn... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:Boughton-Smit... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:CookTony RTR | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:CooperSally... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:Fraser-RaeLyn... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:HallamKayK | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:HamleyPeterP | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:McInallyTomT | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:NichollsDavid... | lld:pubmed |
| pubmed-article:12620067 | pubmed:author | pubmed-author:PimmAusten... | lld:pubmed |
| pubmed-article:12620067 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12620067 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:12620067 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:12620067 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12620067 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12620067 | pubmed:pagination | 913-6 | lld:pubmed |
| pubmed-article:12620067 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:12620067 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12620067 | pubmed:articleTitle | 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. | lld:pubmed |
| pubmed-article:12620067 | pubmed:affiliation | Department of Medicinal Chemistry, AstraZeneca R & D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK. Alan.C.Tinker@Astrazeneca.com | lld:pubmed |
| pubmed-article:12620067 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12620067 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12620067 | lld:pubmed |
