| pubmed-article:12618528 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0015695 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0166417 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C1444749 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0436331 | lld:lifeskim |
| pubmed-article:12618528 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:12618528 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12618528 | pubmed:dateCreated | 2003-3-5 | lld:pubmed |
| pubmed-article:12618528 | pubmed:abstractText | To elucidate the function of PPARgamma in leptin-deficient mouse (ob/ob) liver, a PPARgamma liver-null mouse on an ob/ob background, ob/ob-PPARgamma(fl/fl)AlbCre(+), was produced using a floxed PPARgamma allele, PPARgamma(fl/fl), and Cre recombinase under control of the albumin promoter (AlbCre). The liver of ob/ob-PPARgamma(fl/fl)AlbCre(+) mice had a deletion of exon 2 and a corresponding loss of full-length PPARgamma mRNA and protein. The PPARgamma-deficient liver in ob/ob mice was smaller and had a dramatically decreased triglyceride (TG) content compared with equivalent mice lacking the AlbCre transgene (ob/ob-PPARgamma(fl/fl)AlbCre(-)). Messenger RNA levels of the hepatic lipogenic genes, fatty acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA desaturase-1, were reduced in ob/ob-PPARgamma(fl/fl)AlbCre(+) mice, and the levels of serum TG and FFA in ob/ob-PPARgamma(fl/fl)AlbCre(+) mice were significantly higher than in the control ob/ob-PPARgamma(fl/fl)AlbCre(-) mice. Rosiglitazone treatment exacerbated the fatty liver in ob/ob-PPARgamma(fl/fl)AlbCre(-) mice compared with livers from nonobese Cre(-) mice; there was no effect of rosiglitazone in ob/ob-PPARgamma(fl/fl)AlbCre(+) mice. The deficiency of hepatic PPARgamma further aggravated the severity of diabetes in ob/ob mice due to decreased insulin sensitivity in muscle and fat. These data indicate that hepatic PPARgamma plays a critical role in the regulation of TG content and in the homeostasis of blood glucose and insulin resistance in steatotic diabetic mice. | lld:pubmed |
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| pubmed-article:12618528 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12618528 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12618528 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12618528 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12618528 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12618528 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:LambertGilles... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:GonzalezFrank... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:WardJerrold... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:ReitmanMarc... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:MatsusueKimih... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:HaluzikMartin... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:GavrilovaOksa... | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:YimSun-HeeSH | lld:pubmed |
| pubmed-article:12618528 | pubmed:author | pubmed-author:BrewerBryanBJ... | lld:pubmed |
| pubmed-article:12618528 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12618528 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:12618528 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12618528 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12618528 | pubmed:pagination | 737-47 | lld:pubmed |
