Linked Life Data

12614286

Source:http://linkedlifedata.com/resource/pubmed/id/12614286

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pubmed-article:12614286pubmed:abstractTextCorticosteroids withdrawal from immunosuppressive regimens has thus far been associated with increased risk of acute rejection episodes. In this study, basiliximab, a chimeric monoclonal interleukin-2 receptor antagonist, added to a maintenance regimen consisting of cyclosporine microemulsion and mycophenolate mofetil was studied for its effectiveness in allowing early corticosteroid withdrawal in de novo renal allograft recipients. Primary renal transplant recipients receiving basiliximab, cyclosporine-microemulsion, and mycophenolate mofetil, were randomized to either corticosteroid withdrawal at day four post-transplantation (n = 40) or standard steroid therapy (n = 43). The primary endpoint was the incidence of biopsy-proven acute rejection episodes. Randomized subjects who underwent transplantation and received at least one dose of basiliximab were analyzed in an intent-to-treat fashion. The incidence of biopsy-proven acute rejection at 12 months was not significantly different between the steroid withdrawal group (20%) and the standard treatment group (16%). Patient and graft survival was 100% in the steroid withdrawal group while one death in a patient with a functioning graft occurred in the standard steroid group. Seventy-two percent of the steroid withdrawal group remained off steroids at 6 months post-transplant. Allograft function and incidence of adverse events and infections were similar between the two groups. Rapid and early corticosteroid withdrawal among renal transplant recipients receiving basiliximab induction and daily therapy with cyclosporine-microemulsion and mycophenolate mofetil was not associated with an increased risk of acute rejection.lld:pubmed
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pubmed-article:12614286pubmed:dateRevised2007-2-14lld:pubmed
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pubmed-article:12614286pubmed:articleTitleMulticenter randomized prospective trial of steroid withdrawal in renal transplant recipients receiving basiliximab, cyclosporine microemulsion and mycophenolate mofetil.lld:pubmed
pubmed-article:12614286pubmed:affiliationUniversity of California-San Francisco, San Francisco, CA, USA. vincentif@surgery.ucsf.edulld:pubmed
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pubmed-article:12614286pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:12614286pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:12614286pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:12614286pubmed:publicationTypeMulticenter Studylld:pubmed
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