| pubmed-article:12595307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12595307 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:12595307 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12595307 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:12595307 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:12595307 | lifeskim:mentions | umls-concept:C0939537 | lld:lifeskim |
| pubmed-article:12595307 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12595307 | pubmed:dateCreated | 2003-6-5 | lld:pubmed |
| pubmed-article:12595307 | pubmed:abstractText | The chronic myelogenous leukemia (CML)-like myeloproliferative disorder observed in the BCR/ABL murine bone marrow transduction and transplantation model shares several features with the human disease, including a high response rate to the tyrosine kinase inhibitor imatinib mesylate (STI571). To study the impact of chronic imatinib mesylate treatment on the CML-like illness, mice were maintained on therapeutic doses of this drug and serially monitored. Unexpectedly, despite excellent systemic control of the CML-like illness, many of the mice developed progressive neurologic deficits after 2 to 4 months of imatinib mesylate therapy because of central nervous system (CNS) leukemia. Analysis of imatinib mesylate cerebral spinal fluid concentrations revealed levels 155- fold lower than in plasma. Thus, in the mouse, the limited ability of imatinib mesylate to cross the blood-brain barrier allowed the CNS to become a sanctuary for Bcr/Abl-induced leukemia. This model will be a useful tool for the future study of novel anti-CML drugs and in better defining the mechanisms for limited imatinib mesylate penetration into the CNS. | lld:pubmed |
| pubmed-article:12595307 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12595307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12595307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12595307 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12595307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12595307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12595307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12595307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12595307 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12595307 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12595307 | pubmed:author | pubmed-author:RichardsonJam... | lld:pubmed |
| pubmed-article:12595307 | pubmed:author | pubmed-author:IlariaRobert... | lld:pubmed |
| pubmed-article:12595307 | pubmed:author | pubmed-author:WolffNicholas... | lld:pubmed |
| pubmed-article:12595307 | pubmed:author | pubmed-author:EgorinMerrill... | lld:pubmed |
| pubmed-article:12595307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12595307 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12595307 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:12595307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12595307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12595307 | pubmed:pagination | 5010-3 | lld:pubmed |
| pubmed-article:12595307 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
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| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:meshHeading | pubmed-meshheading:12595307... | lld:pubmed |
| pubmed-article:12595307 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12595307 | pubmed:articleTitle | The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. | lld:pubmed |
| pubmed-article:12595307 | pubmed:affiliation | Division of Hematology/Oncology, Department of Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390, USA. | lld:pubmed |
| pubmed-article:12595307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12595307 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12595307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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