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pubmed-article:1259275pubmed:authorpubmed-author:TashimaC KCKlld:pubmed
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pubmed-article:1259275pubmed:otherAbstractPIP: This letter briefly reports a case linking the appearance of overt diabetes mellitus to progestational therapy, and is intended as an addition to the literature associating insulin-dependent diabetes with progestational therapy. A 51-year-old white woman, who had undergone masectomy and prophylactic oophorectomy, had no history of glucose intolerance and was given Prednisolone (15 mg daily) postoophorectomy. Interval clinical evaluations of glucose levels were between 184 and 223 mg/dl during estrogen therapy. Tumor recurrence 12 years later forced withdrawal of estrogen therapy, and the patient was placed on trial therapy with megestrol acetate (40 mg, 4 times daily). 6 weeks after initiation of progestational therapy, the patient was admitted with a glucose level of 400 mg/dl and a 4+ acetone reading in her urine. Insulin therapy was instituted; megestrol acetate was withdrawn; but the diabetes was not reversed and insulin treatment continues. The author compares this case with others previously reported where medroxyprogesterone acetate was the progestational agent apparently causing irreversible diabetes mellitus.lld:pubmed
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pubmed-article:1259275pubmed:year1976lld:pubmed
pubmed-article:1259275pubmed:articleTitleLetter: Medroxyprogesterone acetate and diabetes mellitus.lld:pubmed
pubmed-article:1259275pubmed:publicationTypeJournal Articlelld:pubmed
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