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| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
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| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1420085 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1749524 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12588979 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:12588979 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12588979 | pubmed:dateCreated | 2003-2-17 | lld:pubmed |
| pubmed-article:12588979 | pubmed:abstractText | The replication-dependent histone mRNAs, the only eukaryotic mRNAs that do not have poly(A) tails, are present only in S-phase cells. Coordinate posttranscriptional regulation of histone mRNAs is mediated by the stem-loop at the 3' end of histone mRNAs. The protein that binds the 3' end of histone mRNA, stem-loop binding protein (SLBP), is required for histone pre-mRNA processing and is involved in multiple aspects of histone mRNA metabolism. SLBP is also regulated during the cell cycle, accumulating as cells enter S phase and being rapidly degraded as cells exit S phase. Mutation of any residues in a TTP sequence (amino acids 60 to 62) or mutation of a consensus cyclin binding site (amino acids 99 to 104) stabilizes SLBP in G2 and mitosis. These two threonines are phosphorylated in late S phase, as determined by mass spectrometry (MS) of purified SLBP from late S-phase cells, triggering SLBP degradation. Cells that express a stable SLBP still degrade histone mRNA at the end of S phase, demonstrating that degradation of SLBP is not required for histone mRNA degradation. Nuclear extracts from G1 and G2 cells are deficient in histone pre-mRNA processing, which is restored by addition of recombinant SLBP, indicating that SLBP is the only cell cycle-regulated factor required for histone pre-mRNA processing. | lld:pubmed |
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| pubmed-article:12588979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12588979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12588979 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12588979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12588979 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12588979 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:DominskiZbign... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:MarzluffWilli... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:BorchersChris... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:YangXiao-CuiX... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:RaskaChristy... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:ZhengLianxing... | lld:pubmed |
| pubmed-article:12588979 | pubmed:author | pubmed-author:ElmsPhillipP | lld:pubmed |
| pubmed-article:12588979 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12588979 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12588979 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12588979 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12588979 | pubmed:pagination | 1590-601 | lld:pubmed |
| pubmed-article:12588979 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12588979 | pubmed:meshHeading | pubmed-meshheading:12588979... | lld:pubmed |
