| pubmed-article:12586341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C1622372 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C0753837 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C1420414 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C1760028 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:12586341 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12586341 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:12586341 | pubmed:dateCreated | 2003-2-14 | lld:pubmed |
| pubmed-article:12586341 | pubmed:abstractText | Stimulation of the epidermal growth factor receptor (EGFR) produces membrane ruffles through the small G protein Rac1; however, the signaling pathway from EGFR to Rac1 has not yet been clarified. Here, we show that autophosphorylation of EGFR at tyrosine 992 is required for EGF-induced membrane ruffle formation in CHO cells. Signaling from the autophosphorylated tyrosine 992 appears to be mediated by phospholipase C (PLC) gamma 1. Furthermore, activation of Rac1 by EGF is inhibited by a PLC inhibitor. These results, taken together, suggest that autophosphorylation of EGFR at tyrosine 992 and the subsequent PLC gamma 1 activation transduce the signal to Rac1 to induce membrane ruffle formation. | lld:pubmed |
| pubmed-article:12586341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12586341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12586341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12586341 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12586341 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:OkabayashiYos... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:KasugaMasatoM | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:WatanabeHiros... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:KidoYoshiakiY | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:SasakiTakehik... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:KanahoYasunor... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:YamazakiMasak... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:MaehamaTomohi... | lld:pubmed |
| pubmed-article:12586341 | pubmed:author | pubmed-author:NogamiMasahir... | lld:pubmed |
| pubmed-article:12586341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12586341 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12586341 | pubmed:volume | 536 | lld:pubmed |
| pubmed-article:12586341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12586341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12586341 | pubmed:pagination | 71-6 | lld:pubmed |
| pubmed-article:12586341 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:meshHeading | pubmed-meshheading:12586341... | lld:pubmed |
| pubmed-article:12586341 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12586341 | pubmed:articleTitle | Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation. | lld:pubmed |
| pubmed-article:12586341 | pubmed:affiliation | Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. | lld:pubmed |
| pubmed-article:12586341 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12586341 | lld:pubmed |
