| pubmed-article:12578828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C1257825 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C1420865 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C1705914 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C1314677 | lld:lifeskim |
| pubmed-article:12578828 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:12578828 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12578828 | pubmed:dateCreated | 2003-4-21 | lld:pubmed |
| pubmed-article:12578828 | pubmed:abstractText | p53-binding protein-1 (53BP1) is phosphorylated in response to DNA damage and rapidly relocalizes to presumptive sites of DNA damage along with Mre11 and the phosphorylated histone 2A variant, gamma-H2AX. 53BP1 associates with the BRCA1 tumor suppressor, and knock-down experiments with small interfering RNA have revealed a role for the protein in the checkpoint response to DNA damage. By generating mice defective in m53BP1 (m53BP1(tr/tr)), we have created an animal model to further explore its biochemical and genetic roles in vivo. We find that m53BP1(tr/tr) animals are growth-retarded and show various immune deficiencies including a specific reduction in thymus size and T cell count. Consistent with a role in responding to DNA damage, we find that m53BP1(tr/tr) mice are sensitive to ionizing radiation (gamma-IR), and cells from these animals exhibit chromosomal abnormalities consistent with defects in DNA repair. Thus, 53BP1 is a critical element in the DNA damage response and plays an integral role in maintaining genomic stability. | lld:pubmed |
| pubmed-article:12578828 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12578828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12578828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12578828 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12578828 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:WoodR WRW | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:HoV VVV | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:KellemsRodney... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:ElledgeStephe... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:HittelmanWalt... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:CarpenterPhil... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:MoralesJulio... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:XiaZhenfangZ | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:AldrichMeliss... | lld:pubmed |
| pubmed-article:12578828 | pubmed:author | pubmed-author:RosalesCorina... | lld:pubmed |
| pubmed-article:12578828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12578828 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:12578828 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12578828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12578828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12578828 | pubmed:pagination | 14971-7 | lld:pubmed |
| pubmed-article:12578828 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:meshHeading | pubmed-meshheading:12578828... | lld:pubmed |
| pubmed-article:12578828 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12578828 | pubmed:articleTitle | Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. | lld:pubmed |
| pubmed-article:12578828 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:12578828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12578828 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12578828 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12578828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:27223 | entrezgene:pubmed | pubmed-article:12578828 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12578828 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12578828 | lld:pubmed |
