| pubmed-article:12577065 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C1155781 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:12577065 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12577065 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12577065 | pubmed:dateCreated | 2003-3-20 | lld:pubmed |
| pubmed-article:12577065 | pubmed:abstractText | The activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) and NuMA (nuclear-mitotic apparatus protein) from the inhibitory binding of importin-alpha and -beta. We report here that Ran-GTP stimulates the interaction between TPX2 and the Xenopus Aurora A kinase, Eg2. This interaction causes TPX2 to stimulate both the phosphorylation and the kinase activity of Eg2 in a microtubule-dependent manner. We show that TPX2 and microtubules promote phosphorylation of Eg2 by preventing phosphatase I (PPI)-induced dephosphorylation. Activation of Eg2 by TPX2 and microtubules is inhibited by importin-alpha and -beta, although this inhibition is overcome by Ran-GTP both in the egg extracts and in vitro with purified proteins. As the phosphorylation of Eg2 stimulated by the Ran-GTP-TPX2 pathway is essential for spindle assembly, we hypothesize that the Ran-GTP gradient established by the condensed chromosomes is translated into the Aurora A kinase gradient on the microtubules to regulate spindle assembly and dynamics. | lld:pubmed |
| pubmed-article:12577065 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12577065 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12577065 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12577065 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12577065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12577065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12577065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12577065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12577065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12577065 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12577065 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12577065 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:PrigentClaude... | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:Guam | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:ZhengYixianY | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:TsaiMing-Ying... | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:WieseChristia... | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:MartinOnaO | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:DonovanPeterP | lld:pubmed |
| pubmed-article:12577065 | pubmed:author | pubmed-author:RudermanJoanJ | lld:pubmed |
| pubmed-article:12577065 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12577065 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:12577065 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12577065 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12577065 | pubmed:pagination | 242-8 | lld:pubmed |
| pubmed-article:12577065 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:meshHeading | pubmed-meshheading:12577065... | lld:pubmed |
| pubmed-article:12577065 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12577065 | pubmed:articleTitle | A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. | lld:pubmed |
| pubmed-article:12577065 | pubmed:affiliation | Department of Embryology, Carnegie Institution of Washington/Howard Hughes Medical Institute, Baltimore, MD 21210, USA. | lld:pubmed |
| pubmed-article:12577065 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12577065 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12577065 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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