| pubmed-article:12576486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12576486 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:12576486 | lifeskim:mentions | umls-concept:C0040135 | lld:lifeskim |
| pubmed-article:12576486 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:12576486 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12576486 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12576486 | pubmed:dateCreated | 2003-4-28 | lld:pubmed |
| pubmed-article:12576486 | pubmed:abstractText | Steroid receptor coactivator-1 (SRC-1) is a transcription cofactor that enhances the hormone-dependent action mediated by the thyroid hormone (TH) receptor (TR) as well as other nuclear receptors. However, it is not known whether the SRC-1-mediated activation of TH-regulated gene transcription is TR isoform specific in the pituitary. We generated mice that were deficient in TRalpha and SRC-1 (TRalpha(0/0)SRC-1(-/-)), as well in TRbeta and SRC-1 (TRbeta(-/-)SRC-1(-/-)), and thyroid function tests and effects of TH deprivation and TH treatment were compared with wild-type mice or mice with deletion of either TRs or SRC-1 alone. We have shown that 1) TRbeta(-/-)SRC-1(-/-) mice demonstrate more severe TH resistance than either the SRC-1(-/-) or TRbeta(-/-) mice; the additive effect indicates that SRC-1 has an independent role in TH action over that of TRbeta; 2) SRC-1 facilitates TRbeta and TRalpha-mediated down-regulation of TSH, as TRalpha(0/0)SRC-1(-/-) mice demonstrate TH resistance rather than hypersensitivity as seen in TRalpha(0/0)mice; and 3) a compensatory increase in SRC-1 expression is associated with the TH hypersensitivity seen in TRalpha-deficient animals. We conclude that SRC-1 action in the pituitary mediates TH action via specific TR subtypes. | lld:pubmed |
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| pubmed-article:12576486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12576486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12576486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12576486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12576486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12576486 | pubmed:month | May | lld:pubmed |
| pubmed-article:12576486 | pubmed:issn | 0888-8809 | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:O'MalleyBert... | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:ChassandeOliv... | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:GauthierKarin... | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:SamarutJacque... | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:WeissRoy ERE | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:XuJianmingJ | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:KooEugeneE | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:MurataYoshiha... | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:SeoHisaoH | lld:pubmed |
| pubmed-article:12576486 | pubmed:author | pubmed-author:SadowPeter... | lld:pubmed |
| pubmed-article:12576486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12576486 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:12576486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12576486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12576486 | pubmed:pagination | 882-94 | lld:pubmed |
| pubmed-article:12576486 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12576486 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12576486 | pubmed:articleTitle | Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary. | lld:pubmed |
| pubmed-article:12576486 | pubmed:affiliation | Department of Medicine, University of Chicago, Illinois, USA. | lld:pubmed |
| pubmed-article:12576486 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12576486 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12576486 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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