| pubmed-article:12574812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0010536 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12574812 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12574812 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12574812 | pubmed:dateCreated | 2003-2-7 | lld:pubmed |
| pubmed-article:12574812 | pubmed:abstractText | P-selectin is rapidly translocated from platelet alpha-granules following activation. Intracellular cyclic AMP (cAMP) is a potent inhibitory pathway that results in global downregulation of platelet activation. While cAMP-dependent protein kinase (PKA) has long been considered as the main mediator of cAMP-dependent effects, no study has yet evaluated its effect on P-selectin expression in human platelets. Pretreatment of thrombin-stimulated platelets with forskolin resulted in a concentration- dependent inhibition of P-selectin expression that correlated with adenylyl cyclase activity. Inhibition of PKA with H-89 reversed cAMP-induced inhibition of P-selectin while cGMP-dependent protein kinase (PKG) inhibition with KT5823 significantly potentiated cAMP-dependent inhibition of P-selectin. Similar results were also observed in a platelet/neutrophil binding assay. In conclusion, cAMP-induced inhibition of P-selectin expression is, in large part, mediated through activation of PKA. PKG appears to be solicited for P-selectin expression when cAMP levels are elevated which suggest a cAMP/PKG-dependent pathway of platelet activation. | lld:pubmed |
| pubmed-article:12574812 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12574812 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12574812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12574812 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12574812 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:12574812 | pubmed:author | pubmed-author:RousseauGuyG | lld:pubmed |
| pubmed-article:12574812 | pubmed:author | pubmed-author:MerhiYahyeY | lld:pubmed |
| pubmed-article:12574812 | pubmed:author | pubmed-author:LibersanDanie... | lld:pubmed |
| pubmed-article:12574812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12574812 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:12574812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12574812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12574812 | pubmed:pagination | 310-7 | lld:pubmed |
| pubmed-article:12574812 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12574812 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12574812 | pubmed:articleTitle | Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets. | lld:pubmed |
| pubmed-article:12574812 | pubmed:affiliation | Montreal Heart Institute, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:12574812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12574812 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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