| pubmed-article:12574125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12574125 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:12574125 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12574125 | lifeskim:mentions | umls-concept:C1333891 | lld:lifeskim |
| pubmed-article:12574125 | lifeskim:mentions | umls-concept:C1511737 | lld:lifeskim |
| pubmed-article:12574125 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12574125 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12574125 | pubmed:dateCreated | 2003-2-7 | lld:pubmed |
| pubmed-article:12574125 | pubmed:abstractText | Transcriptional activation is associated commonly with recruitment of histone acetylases, while repression involves histone deacetylases (HDACs). Here, we provide evidence to suggest that STAT5 activates gene expression by recruiting HDAC. The interleukin-3 (IL-3)-dependent expression of the Id-1 gene, encoding a helix-loop-helix (HLH) transcriptional inhibitor, is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE), but is inhibited by HDAC inhibitors in Ba/F3 cells. STAT5 interacts with HDAC1 in the PBE region, resulting in deacetylation of histones, as well as C/EBPbeta, whose acetylation diminishes its DNA-binding activity. Consistently, expression of an acetylation-resistant mutant of C/EBPbeta results in IL-3-independent expression of the Id-1 gene. Thus, we propose a novel mechanism by which STAT5 mediates the deacetylation of C/EBPbeta, allowing transcriptional activation. | lld:pubmed |
| pubmed-article:12574125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12574125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12574125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12574125 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12574125 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:12574125 | pubmed:author | pubmed-author:KohT JTJ | lld:pubmed |
| pubmed-article:12574125 | pubmed:author | pubmed-author:LANVV | lld:pubmed |
| pubmed-article:12574125 | pubmed:author | pubmed-author:SunXiao-HongX... | lld:pubmed |
| pubmed-article:12574125 | pubmed:author | pubmed-author:KimSeung-Hwan... | lld:pubmed |
| pubmed-article:12574125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12574125 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:12574125 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12574125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12574125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12574125 | pubmed:pagination | 893-904 | lld:pubmed |
| pubmed-article:12574125 | pubmed:dateRevised | 2010-7-14 | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
| pubmed-article:12574125 | pubmed:meshHeading | pubmed-meshheading:12574125... | lld:pubmed |
