Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12573241rdf:typepubmed:Citationlld:pubmed
pubmed-article:12573241lifeskim:mentionsumls-concept:C0015576lld:lifeskim
pubmed-article:12573241lifeskim:mentionsumls-concept:C0020792lld:lifeskim
pubmed-article:12573241lifeskim:mentionsumls-concept:C0033681lld:lifeskim
pubmed-article:12573241lifeskim:mentionsumls-concept:C0282535lld:lifeskim
pubmed-article:12573241lifeskim:mentionsumls-concept:C1519063lld:lifeskim
pubmed-article:12573241pubmed:issue2lld:pubmed
pubmed-article:12573241pubmed:dateCreated2003-2-7lld:pubmed
pubmed-article:12573241pubmed:abstractTextTec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the SH3 domain via a transphosphorylation mechanism, which for Bruton's tyrosine kinase (Btk) affects tyrosine 223. We found that TFKs phosphorylate preferentially their own SH3 domains, but differentially phosphorylate other member family SH3 domains, whereas non-related SH3 domains are not phosphorylated. We demonstrate that SH3 domains are good and reliable substrates. We observe that transphosphorylation is selective not only for SH3 domains, but also for dual SH3SH2 domains. However, the dual domain is phosphorylated more effectively. The major phosphorylation sites were identified as conserved tyrosines, for Itk Y180 and for Bmx Y215, both sites being homologous to the Y223 site in Btk. There is, however, one exception because the Tec-SH3 domain is phosphorylated at a non-homologous site, nevertheless a conserved tyrosine, Y206. Consistent with these findings, the 3D structures for SH3 domains point out that these phosphorylated tyrosines are located on the ligand-binding surface. Because a number of Tec family kinases are coexpressed in cells, it is possible that they could regulate the activity of each other through transphosphorylation.lld:pubmed
pubmed-article:12573241pubmed:languageenglld:pubmed
pubmed-article:12573241pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:citationSubsetIMlld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12573241pubmed:statusMEDLINElld:pubmed
pubmed-article:12573241pubmed:monthFeblld:pubmed
pubmed-article:12573241pubmed:issn0006-3002lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:SmithC I...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:NoreBeston...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:MattssonPekka...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:RönnstrandLar...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:LennartssonJo...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:LöwPeterPlld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:AntonssonPerPlld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:BäckesjöCarl-...lld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:WestlundAnnaAlld:pubmed
pubmed-article:12573241pubmed:authorpubmed-author:HanssonHenrik...lld:pubmed
pubmed-article:12573241pubmed:issnTypePrintlld:pubmed
pubmed-article:12573241pubmed:day21lld:pubmed
pubmed-article:12573241pubmed:volume1645lld:pubmed
pubmed-article:12573241pubmed:ownerNLMlld:pubmed
pubmed-article:12573241pubmed:authorsCompleteYlld:pubmed
pubmed-article:12573241pubmed:pagination123-32lld:pubmed
pubmed-article:12573241pubmed:dateRevised2011-11-2lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:meshHeadingpubmed-meshheading:12573241...lld:pubmed
pubmed-article:12573241pubmed:year2003lld:pubmed
pubmed-article:12573241pubmed:articleTitleIdentification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.lld:pubmed
pubmed-article:12573241pubmed:affiliationKarolinska Institutet, Clinical Research Center (CRC) at Novum, Huddinge University Hospital, SE-141 86, Huddinge, Sweden. beston.nore@crc.ki.selld:pubmed
pubmed-article:12573241pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12573241pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:12573241pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:25entrezgene:pubmedpubmed-article:12573241lld:entrezgene
entrez-gene:660entrezgene:pubmedpubmed-article:12573241lld:entrezgene
entrez-gene:695entrezgene:pubmedpubmed-article:12573241lld:entrezgene
entrez-gene:3702entrezgene:pubmedpubmed-article:12573241lld:entrezgene
entrez-gene:7006entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12573241lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12573241lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12573241lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12573241lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12573241lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12573241lld:pubmed