| pubmed-article:12570874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C1417701 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C0018966 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:12570874 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12570874 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:12570874 | pubmed:dateCreated | 2003-4-18 | lld:pubmed |
| pubmed-article:12570874 | pubmed:abstractText | The transcription factor Nrf2, which normally exists in an inactive state as a consequence of binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent stimuli. Alteration of the Nrf2-Keap1 interaction enables Nrf2 to translocate to the nucleus, bind to the antioxidant-responsive element (ARE) and initiate the transcription of genes coding for detoxifying enzymes and cytoprotective proteins. This response is also triggered by a class of electrophilic compounds including polyphenols and plant-derived constituents. Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a redox-sensitive inducible protein that provides protection against various forms of stress. Here, we show that in renal epithelial cells both curcumin and CAPE stimulate the expression of Nrf2 in a concentration- and time-dependent manner. This effect was associated with a significant increase in HO-1 protein expression and haem oxygenase activity. From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs. Moreover, using antibodies and specific inhibitors of the mitogen-activated protein kinase (MAPK) pathways, we provide data implicating p38 MAPK in curcumin-mediated ho-1 induction. Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway. | lld:pubmed |
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| pubmed-article:12570874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12570874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12570874 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12570874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12570874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12570874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12570874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12570874 | pubmed:month | May | lld:pubmed |
| pubmed-article:12570874 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:MotterliniRob... | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:ForestiRobert... | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:GreenColin... | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:AlamJawedJ | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:GongPengfeiP | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:HoqueMarthaM | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:KilleenErinE | lld:pubmed |
| pubmed-article:12570874 | pubmed:author | pubmed-author:BalogunElisab... | lld:pubmed |
| pubmed-article:12570874 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12570874 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12570874 | pubmed:volume | 371 | lld:pubmed |
| pubmed-article:12570874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12570874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12570874 | pubmed:pagination | 887-95 | lld:pubmed |
| pubmed-article:12570874 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12570874 | pubmed:year | 2003 | lld:pubmed |
