| pubmed-article:12565143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0162585 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:12565143 | lifeskim:mentions | umls-concept:C0049231 | lld:lifeskim |
| pubmed-article:12565143 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12565143 | pubmed:dateCreated | 2003-2-4 | lld:pubmed |
| pubmed-article:12565143 | pubmed:abstractText | We examined the effect of 5-hydroxyindole (5-HI) on the potentiation of 5-hydroytryptamine (5-HT)(3) receptor function by ethanol (EtOH) so as to study whether EtOH potentiates channel function through increasing activation or blocking desensitization. We measured 5-HT(3) receptor current using a whole-cell voltage clamp technique with a method of rapid drug application in NCB-20 neuroblastoma cells. The 5-HI, an agent that block receptor desensitization, increased the decay time constant (tau), not the peak of 5-HT(3) receptor-mediated currents induced by 10 microM 5-HT. EtOH did not change the peak amplitude and tau of the current induced by 10 microM 5-HT. Coapplication of EtOH and 5-HI with 5-HT caused no increase in the peak currents, but tau was further increased. Therefore, a further block in desensitization could be induced by 5-HI, despite the presence of EtOH. These results indicate that EtOH potentiates 5-HT(3) receptor function, with these effects due at least in part by increasing channel activation rather than by blocking desensitization. | lld:pubmed |
| pubmed-article:12565143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12565143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12565143 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12565143 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:KimOk NyuON | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:LeeSang BokSB | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:KimSeong... | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:SungKi-WugKW | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:YangHan SooHS | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:ChoiSe JoonSJ | lld:pubmed |
| pubmed-article:12565143 | pubmed:author | pubmed-author:KimKi-JungKJ | lld:pubmed |
| pubmed-article:12565143 | pubmed:copyrightInfo | Copyright 2002 Elsevier Science Ireland Ltd. | lld:pubmed |
| pubmed-article:12565143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12565143 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:12565143 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:12565143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12565143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12565143 | pubmed:pagination | 72-6 | lld:pubmed |
| pubmed-article:12565143 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:meshHeading | pubmed-meshheading:12565143... | lld:pubmed |
| pubmed-article:12565143 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12565143 | pubmed:articleTitle | Effect of 5-hydroxyindole on ethanol potentiation of 5-hydroxytryptamine (5-HT)3 receptor-activated ion current in NCB-20 neuroblastoma cells. | lld:pubmed |
| pubmed-article:12565143 | pubmed:affiliation | Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea. | lld:pubmed |
| pubmed-article:12565143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12565143 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
