Linked Life Data

12560217

Source:http://linkedlifedata.com/resource/pubmed/id/12560217

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pubmed-article:12560217pubmed:abstractTextToll-like receptors (TLRs) are pattern recognition receptors that trigger innate immunity. In this study we investigated the expression of 10 TLRs in human naive and memory B-cell subsets. We report that in human naive B cells most TLRs are expressed at low to undetectable levels, but the expression of TLR9 and TLR10 is rapidly induced following B-cell-receptor (BCR) triggering. In contrast, memory B cells express several TLRs at constitutively high levels. The differential expression of TLR9 correlates with responsiveness to its agonist, CpG DNA. Thus, human memory B cells proliferate and differentiate to immunoglobulin (Ig)-secreting cells in response to CpG, while naive B do so only if simultaneously triggered through the BCR. The BCR-induced expression of TLRs in human naive B cells prevents polyclonal activation in a primary response, because it restricts stimulation to antigen-specific B cells. In contrast, the constitutive expression of TLRs in memory B cells allows polyclonal activation of the entire memory pool. Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase.lld:pubmed
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pubmed-article:12560217pubmed:articleTitleA role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells.lld:pubmed
pubmed-article:12560217pubmed:affiliationInstitute for Research in Biomedicine, Bellinzona, Switzerland. lanzavecchia@irb.unisi.chlld:pubmed
pubmed-article:12560217pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12560217pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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