| pubmed-article:12547703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12547703 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12547703 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:12547703 | lifeskim:mentions | umls-concept:C0035126 | lld:lifeskim |
| pubmed-article:12547703 | lifeskim:mentions | umls-concept:C0009546 | lld:lifeskim |
| pubmed-article:12547703 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12547703 | pubmed:dateCreated | 2003-1-27 | lld:pubmed |
| pubmed-article:12547703 | pubmed:abstractText | The terminal complement components play an important role in mediating tissue injury after ischemia and reperfusion (I/R) injury in rats and mice. However, the specific complement pathways involved in I/R injury are unknown. The role of the alternative pathway in I/R injury may be particularly important, as it amplifies complement activation and deposition. In this study, the role of the alternative pathway in I/R injury was evaluated using factor D-deficient (-/-) and heterozygote (+/-) mice. Gastrointestinal ischemia (GI) was induced by clamping the mesenteric artery for 20 minutes and then reperfused for 3 hours. Sham-operated control mice (+/- versus -/-) had similar baseline intestinal lactate dehydrogenase activity (P = ns). Intestinal lactate dehydrogenase activity was greater in -/- mice compared to +/- mice after GI/R (P = 0.02) thus demonstrating protection in the -/- mice. Intestinal myeloperoxidase activity in +/- mice was significantly greater than -/- mice after GI/R (P < 0.001). Pulmonary myeloperoxidase activity after GI/R was significantly higher in +/- than -/- mice (P = 0.03). Addition of human factor D to -/- animals restored GI/R injury and was prevented by a functionally inhibitory antibody against human factor D. These data suggest that the alternative complement pathway plays an important role in local and remote tissue injury after GI/R. Inhibition of factor D may represent an effective therapeutic approach for GI/R injury. | lld:pubmed |
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| pubmed-article:12547703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12547703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12547703 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12547703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12547703 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12547703 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:ZhaoHuiH | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:BurasJon AJA | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:StahlGregory... | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:FungMichaelM | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:HaoLimingL | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:XuYuanyuanY | lld:pubmed |
| pubmed-article:12547703 | pubmed:author | pubmed-author:MillerMendyM | lld:pubmed |
| pubmed-article:12547703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12547703 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:12547703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12547703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12547703 | pubmed:pagination | 449-55 | lld:pubmed |
| pubmed-article:12547703 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12547703 | pubmed:meshHeading | pubmed-meshheading:12547703... | lld:pubmed |
| pubmed-article:12547703 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12547703 | pubmed:articleTitle | Role for the alternative complement pathway in ischemia/reperfusion injury. | lld:pubmed |
| pubmed-article:12547703 | pubmed:affiliation | Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. gstahl@zeus.bwh.harvard.edu | lld:pubmed |
| pubmed-article:12547703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12547703 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12547703 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11537 | entrezgene:pubmed | pubmed-article:12547703 | lld:entrezgene |
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