| pubmed-article:12543865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C1533585 | lld:lifeskim |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C1334501 | lld:lifeskim |
| pubmed-article:12543865 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12543865 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12543865 | pubmed:dateCreated | 2003-5-20 | lld:pubmed |
| pubmed-article:12543865 | pubmed:abstractText | HOX genes, notably members of the HOXA cluster, and HOX cofactors have increasingly been linked to human leukemia. Intriguingly, HOXD13, a member of the HOXD cluster not normally expressed in hematopoietic cells, was recently identified as a partner of NUP98 in a t(2;11) translocation associated with t-AML/MDS. We have now tested directly the leukemogenic potential of the NUP98-HOXD13 t(2; 11) fusion gene in the murine hematopoietic model. NUP98-HOXD13 strongly promoted growth and impaired differentiation of early hematopoietic progenitor cells in vitro; this effect was dependent on the NUP98 portion and an intact HOXD13 homeodomain. Expression of the NUP98-HOXD13 fusion gene in vivo resulted in a partial impairment of lymphopoiesis but did not induce evident hematologic disease until late after transplantation (more than 5 months), when some mice developed a myeloproliferative-like disease. In contrast, mice transplanted with bone marrow (BM) cells cotransduced with NUP98-HOXD13 and the HOX cofactor Meis1 rapidly developed lethal and transplantable acute myeloid leukemia (AML), with a median disease onset of 75 days. In summary, this study demonstrates that NUP98-HOXD13 can be directly implicated in the molecular process leading to leukemic transformation, and it supports a model in which the transforming properties of NUP98-HOXD13 are mediated through HOX-dependent pathways. | lld:pubmed |
| pubmed-article:12543865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12543865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543865 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12543865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12543865 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12543865 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:AplanPeter... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:PineaultNicol... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:HumphriesR... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:Feuring-Buske... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:HoggeDonna... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:AbramovichCar... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:BuskeChristia... | lld:pubmed |
| pubmed-article:12543865 | pubmed:author | pubmed-author:RostenPattyP | lld:pubmed |
| pubmed-article:12543865 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12543865 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12543865 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:12543865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12543865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12543865 | pubmed:pagination | 4529-38 | lld:pubmed |
| pubmed-article:12543865 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12543865 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12543865 | pubmed:articleTitle | Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. | lld:pubmed |
| pubmed-article:12543865 | pubmed:affiliation | Terry Fox Laboratory, Vancouver, BC, Canada. | lld:pubmed |
| pubmed-article:12543865 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12543865 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12543865 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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