pubmed-article:12539049 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0206694 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C1424876 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C1155452 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C1706214 | lld:lifeskim |
pubmed-article:12539049 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:12539049 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:12539049 | pubmed:dateCreated | 2003-1-31 | lld:pubmed |
pubmed-article:12539049 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:abstractText | Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. Here we identify a new mechanism for disrupting Notch signaling in human tumorigenesis, characterized by altered function of a new ortholog of the Drosophila melanogaster Notch co-activator molecule Mastermind. We cloned the t(11;19) translocation that underlies the most common type of human malignant salivary gland tumor. This rearrangement fuses exon 1 from a novel gene of unknown function at 19p13, termed mucoepidermoid carcinoma translocated 1 (MECT1), with exons 2-5 of a novel member of the Mastermind-like gene family (MAML2) at 11q21 (ref. 3). Similar to D. melanogaster Mastermind and MAML1 (refs. 4,5), full-length MAML2 functioned as a CSL (CBF-1, suppressor of hairless and Lag-1)-dependent transcriptional co-activator for ligand-stimulated Notch. In contrast, MECT1-MAML2 activated transcription of the Notch target gene HES1 independently of both Notch ligand and CSL binding sites. MECT1-MAML2 induced foci formation in RK3E epithelial cells, confirming a biological effect for the fusion product. These data suggest a new mechanism to disrupt the function of a Notch co-activator in a common type of malignant salivary gland tumor. | lld:pubmed |
pubmed-article:12539049 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:language | eng | lld:pubmed |
pubmed-article:12539049 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12539049 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12539049 | pubmed:month | Feb | lld:pubmed |
pubmed-article:12539049 | pubmed:issn | 1061-4036 | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:KomiyaTakefum... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:GriffinJames... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:StoverKristen... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:TononGiovanni... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:KirschIlan... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:El-NaggarAdel... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:KuboAkihitoA | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:KayeFrederic... | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:WuLiziL | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:ModiSanjayS | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:CoxonAmy BAB | lld:pubmed |
pubmed-article:12539049 | pubmed:author | pubmed-author:O'NeilKevinK | lld:pubmed |
pubmed-article:12539049 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12539049 | pubmed:volume | 33 | lld:pubmed |
pubmed-article:12539049 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12539049 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12539049 | pubmed:pagination | 208-13 | lld:pubmed |
pubmed-article:12539049 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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