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pubmed-article:12538854pubmed:abstractTextTemporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of cortical reorganization. Pairing ventral tegmental area stimulation with a sound in a backward conditioning paradigm specifically reduced representations of the paired sound in the primary auditory cortex (AI). This temporal sequence-dependent bidirectional cortical plasticity modulated by dopamine release hypothetically serves to prevent the over-representation of frequently occurring stimuli resulting from their random pairing with unrelated rewards.lld:pubmed
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pubmed-article:12538854pubmed:authorpubmed-author:BaoShaowenSlld:pubmed
pubmed-article:12538854pubmed:authorpubmed-author:ZhangLi ILIlld:pubmed
pubmed-article:12538854pubmed:authorpubmed-author:MerzenichMich...lld:pubmed
pubmed-article:12538854pubmed:authorpubmed-author:ChanVincent...lld:pubmed
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pubmed-article:12538854pubmed:pagination1405-8lld:pubmed
pubmed-article:12538854pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:12538854pubmed:articleTitleSuppression of cortical representation through backward conditioning.lld:pubmed
pubmed-article:12538854pubmed:affiliationKeck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA.lld:pubmed
pubmed-article:12538854pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12538854pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:12538854pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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