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pubmed-article:12532665pubmed:abstractTextBased on the improved insight into the mechanism of blood coagulation in vivo, recombinant factor VIIa (rFVIIa) has been developed as a pro-haemostatic agent. It has been shown that this treatment is effective in patients with haemophilia and an inhibiting antibody against a coagulation factor. Administration of rFVIIa can be effective in the treatment of bleeding episodes and the prevention of perioperative blood loss in a number of other coagulation disorders as well. Initial clinical studies indicate that administration of rFVIIa may also reduce blood loss in patients with severe bleeding without pre-existent abnormalities in blood coagulation, but this requires confirmation in additional clinical trials.lld:pubmed
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pubmed-article:12532665pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12532665pubmed:articleTitle[Treatment and prevention of haemorrhage with recombinant activated factor VII, not only in hemophilia].lld:pubmed
pubmed-article:12532665pubmed:affiliationAcademisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde, Meibergdreef 9, 1105 AZ Amsterdam. m.m.levi@amc.uva.nllld:pubmed
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