| pubmed-article:12531332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12531332 | lifeskim:mentions | umls-concept:C1325725 | lld:lifeskim |
| pubmed-article:12531332 | lifeskim:mentions | umls-concept:C0085432 | lld:lifeskim |
| pubmed-article:12531332 | pubmed:issue | 7-8 | lld:pubmed |
| pubmed-article:12531332 | pubmed:dateCreated | 2003-1-17 | lld:pubmed |
| pubmed-article:12531332 | pubmed:abstractText | Both humoral and cellular immune responses are critical for the control of HIV infection and replication. We have established systems for production of HIV and SIV virus-like particles containing high levels of viral Env proteins using the baculovirus expression system. Evaluation of immunogenicity showed that immunization with virus-like particles induced both cellular and neutralizing antibody responses. Furthermore, mucosal administration of virus-like particles effectively induced both mucosal and systemic immune responses. These results indicate that virus-like particles consisting of HIV structural proteins are an attractive vaccine platform for eliciting anti-viral immune responses, especially neutralizing antibody responses. We have also synthesized codon-optimized genes for HIV Env proteins and evaluated their immunogenicity. Combinations of virus-like particle and DNA-based vaccination are promising for inducing strong cellular and neutralizing antibody responses against HIV. | lld:pubmed |
| pubmed-article:12531332 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12531332 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12531332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12531332 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12531332 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:12531332 | pubmed:author | pubmed-author:YaoQizhiQ | lld:pubmed |
| pubmed-article:12531332 | pubmed:author | pubmed-author:CompansRichar... | lld:pubmed |
| pubmed-article:12531332 | pubmed:author | pubmed-author:YangChinglaiC | lld:pubmed |
| pubmed-article:12531332 | pubmed:author | pubmed-author:BuZhigaoZ | lld:pubmed |
| pubmed-article:12531332 | pubmed:author | pubmed-author:VzorovAndreiA | lld:pubmed |
| pubmed-article:12531332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12531332 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:12531332 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:12531332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12531332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12531332 | pubmed:pagination | 638-43 | lld:pubmed |
| pubmed-article:12531332 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:meshHeading | pubmed-meshheading:12531332... | lld:pubmed |
| pubmed-article:12531332 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12531332 | pubmed:articleTitle | Virus-like particle and DNA-based candidate AIDS vaccines. | lld:pubmed |
| pubmed-article:12531332 | pubmed:affiliation | Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA. | lld:pubmed |
| pubmed-article:12531332 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12531332 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12531332 | pubmed:publicationType | Review | lld:pubmed |
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