| pubmed-article:12519387 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12519387 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:12519387 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:12519387 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:12519387 | lifeskim:mentions | umls-concept:C0003313 | lld:lifeskim |
| pubmed-article:12519387 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:12519387 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12519387 | pubmed:dateCreated | 2003-1-9 | lld:pubmed |
| pubmed-article:12519387 | pubmed:abstractText | Both innate and adaptive immune systems are thought to participate in the pathogenesis of rheumatoid arthritis in adults and children. The experiments reported here were undertaken to examine how immune complexes, potent stimulators of inflammation, may regulate cells of the adaptive immune system. Human T cells were prepared from peripheral blood by negative selection and incubated with bovine serum albumin (BSA)-anti-BSA immune complexes that were formed in the presence or absence of human C1q. C1q-bearing immune complexes, but not unopsonized complexes, elicited both TNF-alpha and IFN-gamma secretion from human T cells. Secretion of both cytokines was time- and dose-dependent. Cross-linking C1q on the cell surface of T cells produced the same results. Cytokine secretion was not inhibited by blocking the C3b receptor (CR1, CD35) on T cells prior to incubation with immune complexes. Reverse transcriptase polymerase chain reaction (RT-PCR) of immune complex-stimulated cells revealed accumulation of both TNF-alpha and IFN-gamma mRNA within 2 h post-stimulation. IL-2 was not detected in cell culture supernatants, but IL-2 receptor alpha chain (CD25) was detected in low density on a small proportion of T cells activated by C1q-bearing immune complexes. Secretion of both cytokines was inhibited partially, but not completely, by IL-10. These experiments show that immune complexes, potent inflammatory mediators, may activate T cells through a novel mechanism. These findings have implications for chronic inflammatory diseases in humans. | lld:pubmed |
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| pubmed-article:12519387 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12519387 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12519387 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12519387 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12519387 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12519387 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12519387 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:12519387 | pubmed:author | pubmed-author:CukMM | lld:pubmed |
| pubmed-article:12519387 | pubmed:author | pubmed-author:JiangKK | lld:pubmed |
| pubmed-article:12519387 | pubmed:author | pubmed-author:JarvisJ NJN | lld:pubmed |
| pubmed-article:12519387 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12519387 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:12519387 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12519387 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12519387 | pubmed:pagination | 61-7 | lld:pubmed |
| pubmed-article:12519387 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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