| pubmed-article:12517346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0525039 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12517346 | lifeskim:mentions | umls-concept:C0009219 | lld:lifeskim |
| pubmed-article:12517346 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12517346 | pubmed:dateCreated | 2003-1-8 | lld:pubmed |
| pubmed-article:12517346 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12517346 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12517346 | pubmed:abstractText | Oxidative damage to DNA generates 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). During DNA replication and repair synthesis, 8-oxodG can pair with cytosine or adenine. The ability to accurately replicate through this lesion depends on the DNA polymerase. We report the first structure of a polymerase with a promutagenic DNA lesion, 8-oxodG, in the confines of its active site. The modified guanine residue is in an anti conformation and forms Watson-Crick hydrogen bonds with an incoming dCTP. To accommodate the oxygen at C8, the 5'-phosphate backbone of the templating nucleotide flips 180 degrees. Thus, the flexibility of the template sugar-phosphate backbone near the polymerase active site is one parameter that influences the anti-syn equilibrium of 8-oxodG. Our results provide insights into the mechanisms employed by polymerases to select the complementary dNTP. | lld:pubmed |
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| pubmed-article:12517346 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12517346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12517346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12517346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12517346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12517346 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12517346 | pubmed:issn | 0969-2126 | lld:pubmed |
| pubmed-article:12517346 | pubmed:author | pubmed-author:WilsonSamuel... | lld:pubmed |
| pubmed-article:12517346 | pubmed:author | pubmed-author:BeardWilliam... | lld:pubmed |
| pubmed-article:12517346 | pubmed:author | pubmed-author:GrollmanArthu... | lld:pubmed |
| pubmed-article:12517346 | pubmed:author | pubmed-author:MillerHollyH | lld:pubmed |
| pubmed-article:12517346 | pubmed:author | pubmed-author:KrahnJoseph... | lld:pubmed |
| pubmed-article:12517346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12517346 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:12517346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12517346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12517346 | pubmed:pagination | 121-7 | lld:pubmed |
| pubmed-article:12517346 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12517346 | pubmed:meshHeading | pubmed-meshheading:12517346... | lld:pubmed |
| pubmed-article:12517346 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12517346 | pubmed:articleTitle | Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. | lld:pubmed |
| pubmed-article:12517346 | pubmed:affiliation | Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA. | lld:pubmed |
| pubmed-article:12517346 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12517346 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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