Linked Life Data

12515722

Source:http://linkedlifedata.com/resource/pubmed/id/12515722

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pubmed-article:12515722pubmed:abstractTextWe report the detection of an interleukin-4 (IL-4) variant whose expression is tightly associated with deprivation apoptosis. It is detected with the 8D4 anti-IL-4 monoclonal antibody (mAb) not only in T helper-2 (Th2) but also in Th1 clones, and primary T cells, and it is a nonsecreted molecule. It is not expressed during primary necrosis. Our data suggest that de novo IL-4 transcription of an alternative IL-4 mRNA (IL-4 delta(13)) is induced during deprivation apoptosis. In HIV-infected patients, increased expression of IL-4 in T cells is highly correlated to increased apoptosis, restricted to 8D4 reactivity (r(2) = 0.84 between % 8D4-8(+) and % 7- amino-actinomycin D-positive [7-AAD(+)] peripheral T cells, P <.0001), and associated with disease progression. The particular reactivity of apoptotic T cells to 8D4 mAb may explain some discordances among studies analyzing the Th1/Th2 balance in HIV infection and questions the function of this intracellular type 2 signal.lld:pubmed
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pubmed-article:12515722pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12515722pubmed:articleTitleA nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection.lld:pubmed
pubmed-article:12515722pubmed:affiliationAntiviral Immunity, Biotherapy, and Vaccines Unit and the Viral Immunopathology Laboratory Unité de Recherche Associée Centre National de la Scientifique 1930, Molecular Medicine Department, Institut Pasteur, Paris, France.lld:pubmed
pubmed-article:12515722pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12515722pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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