| pubmed-article:12514737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1819194 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12514737 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12514737 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12514737 | pubmed:dateCreated | 2003-1-29 | lld:pubmed |
| pubmed-article:12514737 | pubmed:abstractText | Peripheral myelin formation is initiated by axonal cues that trigger a differentiation program in associated Schwann cells. Here, we define one essential differentiation signal: activation of the transcription factor NF-kappaB. In rat sciatic nerves, NF-kappaB was highly upregulated in pre-myelinating Schwann cells, and then its expression progressively declined until it was nearly absent in adults. Similarly, in co-cultures of Schwann cells and sensory neurons, NF-kappaB activation paralleled myelination, and blocking its activity or using cells from mice lacking the NF-kappaB subunit p65 markedly attenuated myelination. Inhibiting NF-kappaB also prevented activation of Oct-6, a transcription factor induced by axonal contact and required for proper myelin formation. These results show that the activation of NF-kappaB is an essential signal for the progression of axon-associated Schwann cells into a myelinating phenotype. | lld:pubmed |
| pubmed-article:12514737 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12514737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12514737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12514737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12514737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12514737 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12514737 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:12514737 | pubmed:author | pubmed-author:CarterBruce... | lld:pubmed |
| pubmed-article:12514737 | pubmed:author | pubmed-author:NickolsJoshua... | lld:pubmed |
| pubmed-article:12514737 | pubmed:author | pubmed-author:ValentineWill... | lld:pubmed |
| pubmed-article:12514737 | pubmed:author | pubmed-author:KanwalSujataS | lld:pubmed |
| pubmed-article:12514737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12514737 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:12514737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12514737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12514737 | pubmed:pagination | 161-7 | lld:pubmed |
| pubmed-article:12514737 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12514737 | pubmed:meshHeading | pubmed-meshheading:12514737... | lld:pubmed |
| pubmed-article:12514737 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12514737 | pubmed:articleTitle | Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation. | lld:pubmed |
| pubmed-article:12514737 | pubmed:affiliation | Vanderbilt University Medical School, Vanderbilt University, Nashville, Tennessee 37232, USA. | lld:pubmed |
| pubmed-article:12514737 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12514737 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12514737 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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