| pubmed-article:12508106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12508106 | lifeskim:mentions | umls-concept:C2611777 | lld:lifeskim |
| pubmed-article:12508106 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:12508106 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:12508106 | pubmed:dateCreated | 2002-12-31 | lld:pubmed |
| pubmed-article:12508106 | pubmed:abstractText | In the past few months, several discoveries relating to the mechanism underlying transcription-coupled DNA repair (TCR) have been reported. These results make it timely to propose a hypothesis for how eukaryotic cells might deal with arrested RNA polymerase II (Pol II) complexes. In this model, the transcription-repair coupling factor Cockayne Syndrome B (or the yeast equivalent Rad26) uses DNA translocase activity to remodel the Pol II-DNA interface, possibly to push the polymerase past the obstruction or to remove it from the DNA so that repair can take place if the obstacle is a DNA lesion. However, when this action is not possible and Pol II is left irreversibly trapped on DNA, the polymerase is instead ubiquitylated and eventually removed by proteolysis. | lld:pubmed |
| pubmed-article:12508106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12508106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12508106 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12508106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12508106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12508106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12508106 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12508106 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:12508106 | pubmed:author | pubmed-author:SvejstrupJesp... | lld:pubmed |
| pubmed-article:12508106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12508106 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12508106 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:12508106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12508106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12508106 | pubmed:pagination | 447-51 | lld:pubmed |
| pubmed-article:12508106 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12508106 | pubmed:meshHeading | pubmed-meshheading:12508106... | lld:pubmed |
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| pubmed-article:12508106 | pubmed:meshHeading | pubmed-meshheading:12508106... | lld:pubmed |
| pubmed-article:12508106 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12508106 | pubmed:articleTitle | Rescue of arrested RNA polymerase II complexes. | lld:pubmed |
| pubmed-article:12508106 | pubmed:affiliation | Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK. j.svejstrup@cancer.org.uk | lld:pubmed |
| pubmed-article:12508106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12508106 | pubmed:publicationType | Review | lld:pubmed |
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