| pubmed-article:12507439 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C0459385 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C1533572 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12507439 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12507439 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12507439 | pubmed:dateCreated | 2002-12-31 | lld:pubmed |
| pubmed-article:12507439 | pubmed:abstractText | We report the first dynamic measurements of tissue nitric oxide (NO) during functional activation of rat somatosensory cortex by electrical forepaw stimulation. Cortical tissue NO was measured electrochemically with rapid-responding recessed microelectrodes (tips <10 microm). Simultaneous blood flow measurements were made by laser-Doppler flowmetry (LDF). NO immediately increased, reaching a peak 125.5 +/- 32.8 (SE) nM above baseline (P < 0.05) within 400 ms after stimulus onset, preceding any LDF changes, and then returned close to prestimulus levels after 2 s (123 signal-averaged trials, 12 rats). Blood flow began rising after a 1-s delay, reaching a peak just before electrical stimulation was ended at t = 4 s. A consistent poststimulus NO undershoot was observed as LDF returned to baseline. These findings complement our previous study (B. M. Ances et al., 2001, Neurosci. Lett. 306, 106-110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation. | lld:pubmed |
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| pubmed-article:12507439 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12507439 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12507439 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12507439 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12507439 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12507439 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12507439 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12507439 | pubmed:issn | 1053-8119 | lld:pubmed |
| pubmed-article:12507439 | pubmed:author | pubmed-author:AncesBeau MBM | lld:pubmed |
| pubmed-article:12507439 | pubmed:author | pubmed-author:DetreJohn AJA | lld:pubmed |
| pubmed-article:12507439 | pubmed:author | pubmed-author:BuerkDonald... | lld:pubmed |
| pubmed-article:12507439 | pubmed:author | pubmed-author:GreenbergJoel... | lld:pubmed |
| pubmed-article:12507439 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12507439 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:12507439 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12507439 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12507439 | pubmed:pagination | 1-9 | lld:pubmed |
| pubmed-article:12507439 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12507439 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12507439 | pubmed:articleTitle | Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats. | lld:pubmed |
| pubmed-article:12507439 | pubmed:affiliation | Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. | lld:pubmed |
| pubmed-article:12507439 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12507439 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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