| pubmed-article:12506012 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0128546 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C1522012 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C2611812 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:12506012 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:12506012 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12506012 | pubmed:dateCreated | 2003-4-22 | lld:pubmed |
| pubmed-article:12506012 | pubmed:abstractText | Recently, it has been demonstrated that macrophage inflammatory protein 1- alpha (MIP-1 alpha) is crucially involved in the development of osteolytic bone lesions in multiple myeloma (MM). The current study was designed to determine the direct effects of MIP-1 alpha on MM cells. Thus, we were able to demonstrate that MIP-1 alpha acts as a potent growth, survival, and chemotactic factor in MM cells. MIP-1 alpha-induced signaling involved activation of the AKT/protein kinase B (PKB) and the mitogen-activated protein kinase (MAPK) pathway. In addition, inhibition of AKT activation by phosphatidylinositol 3- kinase (PI3-K) inhibitors did not influence MAPK activation, suggesting that there is no cross talk between MIP-1 alpha-dependent activation of the PI3-K/AKT and extracellular-regulated kinase (ERK) pathway. Our data suggest that besides its role in development of osteolytic bone destruction, MIP-1 alpha also directly affects cell signaling pathways mediating growth, survival, and migration in MM cells and provide evidence that MIP-1 alpha might play a pivotal role in the pathogenesis of MM. | lld:pubmed |
| pubmed-article:12506012 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12506012 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12506012 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12506012 | pubmed:month | May | lld:pubmed |
| pubmed-article:12506012 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:JanzMartinM | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:DörkenBerndB | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:LentzschSuzan... | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:MaparaMarkus... | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:BargouRalfR | lld:pubmed |
| pubmed-article:12506012 | pubmed:author | pubmed-author:GriesMargaret... | lld:pubmed |
| pubmed-article:12506012 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12506012 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12506012 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:12506012 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12506012 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12506012 | pubmed:pagination | 3568-73 | lld:pubmed |
| pubmed-article:12506012 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12506012 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12506012 | pubmed:articleTitle | Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells. | lld:pubmed |
| pubmed-article:12506012 | pubmed:affiliation | University Medical Center Charite, Department of Hematology, Oncology and Tumorimmunology, Robert-Rössle-Klinik, Campus Buch, Humboldt University, Berlin, Germany. lentzsch@rrk.charite-buch.de | lld:pubmed |
| pubmed-article:12506012 | pubmed:publicationType | Journal Article | lld:pubmed |
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