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pubmed-article:12505681pubmed:abstractTextIn this study we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat. We show that noxious stimulation increases the number of Fos-positive neurons in the dorsal horn of the thoracic and lumbar spinal cord, and that pretreatment with MPEP significantly reduces the number of Fos-positive neurons in these areas. These data indicate that mGlu5 is involved in the transmission of visceral pain in the spinal cord.lld:pubmed
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pubmed-article:12505681pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12505681pubmed:articleTitlemGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation.lld:pubmed
pubmed-article:12505681pubmed:affiliationDepartment of Biomedical Sciences and Biotechnology, University of Brescia, Via Valsabbina 19, 25124, Brescia, Italy. bianchi@med.unibs.itlld:pubmed
pubmed-article:12505681pubmed:publicationTypeJournal Articlelld:pubmed
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