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pubmed-article:12500052pubmed:abstractTextBreast cancer incidence rates are up to five times higher in white women in the United States compared with Asian women in China and Japan. A search for factors that modify estrogen's biological effect differentially between ethnic groups may add to the understanding of international variations in breast cancer risk. Recent evidence indicates that alpha-fetoprotein, a glycoprotein produced by the fetal liver, has important antiestrogenic properties. During pregnancy, alpha-fetoprotein reaches peak concentrations in maternal serum during the third trimester.lld:pubmed
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pubmed-article:12500052pubmed:articleTitleEthnic differences in breast cancer risk: a possible role for pregnancy levels of alpha-fetoprotein?lld:pubmed
pubmed-article:12500052pubmed:affiliationDepartment of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. mats.lambe@mep.ki.selld:pubmed
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