| pubmed-article:12497615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12497615 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12497615 | lifeskim:mentions | umls-concept:C0028768 | lld:lifeskim |
| pubmed-article:12497615 | lifeskim:mentions | umls-concept:C1333254 | lld:lifeskim |
| pubmed-article:12497615 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:12497615 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12497615 | pubmed:dateCreated | 2002-12-23 | lld:pubmed |
| pubmed-article:12497615 | pubmed:abstractText | Obsessive-compulsive disorder (OCD) is a frequent and disabling anxiety disorder. Dopamine (DA) might be involved in its pathophysiology, therefore DA receptors are candidate genes in OCD. A 48-base pairs (bp) polymorphism located in the third exon of the dopamine receptor type 4 (DRD4) gene has been described. Previous case control studies, however, have reported inconclusive results in OCD. The aim of the study was to study this polymorphism in a family-based association study of 55 trios. Extended transmission-disequilibrium test (ETDT) for preferential allele transmission in this group showed an absence of transmission of the allele 2 for the 48 bp repeat polymorphism of the DRD4 gene (P = 0.005). Moreover, in a population-based association study, we found a significantly lower frequency of the allele 2 in patients suffering from OCD compared to ethnically-matched controls (P = 0.02). We found no association of DRD4 48 bp polymorphism with OCD in the subgroup of patients with comorbid tics. This study is the first to report on a significant association of variants of the DRD4 gene in OCD, found on both family- and population-based studies. The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms. | lld:pubmed |
| pubmed-article:12497615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12497615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12497615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12497615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12497615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12497615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12497615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12497615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12497615 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12497615 | pubmed:issn | 1552-4841 | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:LeboyerMarion... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:ChabaneNadiaN | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:BourdelMarie-... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:PoirierMarie-... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:MilletBrunoB | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:KrebsMarie-Od... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:LooHenriH | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:DelormeRichar... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:LeroySophieS | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:Mouren-Simeon... | lld:pubmed |
| pubmed-article:12497615 | pubmed:author | pubmed-author:RouillonFréde... | lld:pubmed |
| pubmed-article:12497615 | pubmed:copyrightInfo | Copyright 2003 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:12497615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12497615 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12497615 | pubmed:volume | 116B | lld:pubmed |
| pubmed-article:12497615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12497615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12497615 | pubmed:pagination | 55-9 | lld:pubmed |
| pubmed-article:12497615 | pubmed:dateRevised | 2008-5-21 | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:meshHeading | pubmed-meshheading:12497615... | lld:pubmed |
| pubmed-article:12497615 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12497615 | pubmed:articleTitle | Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. | lld:pubmed |
| pubmed-article:12497615 | pubmed:affiliation | INSERM E0117 Paris V, University Department of Psychiatry, Sainte-Anne Hospital, Paris, France. millet@chsa.broca.inserm.fr | lld:pubmed |
| pubmed-article:12497615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12497615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12497615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12497615 | lld:pubmed |
