| pubmed-article:12490313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C0282549 | lld:lifeskim |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:12490313 | lifeskim:mentions | umls-concept:C0531691 | lld:lifeskim |
| pubmed-article:12490313 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12490313 | pubmed:dateCreated | 2002-12-19 | lld:pubmed |
| pubmed-article:12490313 | pubmed:abstractText | The fungal metabolite apicidin (cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)) inhibited the growth of HL-60 cells in a concentration-dependent manner (100-1000 nM). At higher concentrations (>300 nM), cell death was induced. At 100 nM, it induced hyperacetylation of histone H4 time-dependently, while trichostatin A induced transient hyperacetylation. Apicidin (10-100 nM) increased the cells having nitroblue tetrazolium-reducing activity and expressing CD11b but not CD14 and CD15. The expression of CD11b by apicidin was long lasting, while that by trichostatin A was transient. In K562 cells, apicidin at 10-100 nM did not inhibit cell growth nor express CD11b, CD14 and CD15. Our findings indicate that apicidin inhibits proliferation and induces the early stage of differentiation of HL-60 cells. | lld:pubmed |
| pubmed-article:12490313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12490313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12490313 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12490313 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:OhuchiKazuoK | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:YamakiKouyaK | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:IshiharaKenji... | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:OhnoTadaoT | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:AhnJong... | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:HiraizumiKenj... | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:ZeeOkPyoO | lld:pubmed |
| pubmed-article:12490313 | pubmed:author | pubmed-author:HongJangJaJ | lld:pubmed |
| pubmed-article:12490313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12490313 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:12490313 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:12490313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12490313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12490313 | pubmed:pagination | 197-206 | lld:pubmed |
| pubmed-article:12490313 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:meshHeading | pubmed-meshheading:12490313... | lld:pubmed |
| pubmed-article:12490313 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12490313 | pubmed:articleTitle | Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells. | lld:pubmed |
| pubmed-article:12490313 | pubmed:affiliation | Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. | lld:pubmed |
| pubmed-article:12490313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12490313 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12490313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12490313 | lld:pubmed |
