| pubmed-article:12482581 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12482581 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:12482581 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12482581 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:12482581 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:12482581 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12482581 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12482581 | pubmed:dateCreated | 2002-12-16 | lld:pubmed |
| pubmed-article:12482581 | pubmed:abstractText | Antioxidants are known to exert a preventive activity against degenerative diseases. Here, we investigated the mechanism of action of three antioxidants: resveratrol, which causes differentiation of HL-60 cells, and hydroxytyrosol and pyrrolidine dithiocarbamate which, in the same model system, activate apoptosis. The expression profile of hydroxytyrosol-treated cells showed the up-regulation of several genes, including c-jun and egr1. Pyrrolidine dithiocarbamate activates both genes, while resveratrol increases uniquely egr1. A selective modulation of signalling pathway explained this finding. All antioxidants up-regulate Erk1/2, while only hydroxytyrosol and pyrrolidine dithiocarbamate activate c-Jun N-terminal kinase (JNK). Since JNK induces apoptosis by Bcl-2 phosphorylation, we investigated this event. Bcl-2 phosphorylation was increased by hydroxytyrosol and pyrrolidine dithiocarbamate and not by resveratrol. Our results indicate that the different phenotypical effects of antioxidants correlate with modulation of selective transduction pathways. | lld:pubmed |
| pubmed-article:12482581 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12482581 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12482581 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12482581 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12482581 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:BorrielloAdri... | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:Della... | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:ZappiaVincenz... | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:CucciollaVale... | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:CrinitiVittor... | lld:pubmed |
| pubmed-article:12482581 | pubmed:author | pubmed-author:IndacoStefani... | lld:pubmed |
| pubmed-article:12482581 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12482581 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:12482581 | pubmed:volume | 532 | lld:pubmed |
| pubmed-article:12482581 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12482581 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12482581 | pubmed:pagination | 289-94 | lld:pubmed |
| pubmed-article:12482581 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12482581 | pubmed:meshHeading | pubmed-meshheading:12482581... | lld:pubmed |
| pubmed-article:12482581 | pubmed:meshHeading | pubmed-meshheading:12482581... | lld:pubmed |
| pubmed-article:12482581 | pubmed:meshHeading | pubmed-meshheading:12482581... | lld:pubmed |
| pubmed-article:12482581 | pubmed:meshHeading | pubmed-meshheading:12482581... | lld:pubmed |
| pubmed-article:12482581 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12482581 | pubmed:articleTitle | Antioxidants induce different phenotypes by a distinct modulation of signal transduction. | lld:pubmed |
| pubmed-article:12482581 | pubmed:affiliation | Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy. fulvio.dellaragione@unina2.it | lld:pubmed |
| pubmed-article:12482581 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12482581 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12482581 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12482581 | lld:pubmed |
