Linked Life Data

12480208

Source:http://linkedlifedata.com/resource/pubmed/id/12480208

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pubmed-article:12480208pubmed:dateCreated2002-12-13lld:pubmed
pubmed-article:12480208pubmed:abstractTextEndothelin-1 (ET-1) is a potent and long-acting vasoconstrictive peptide that has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). ET-1 has been shown to be present in the cerebrospinal fluid of patients after SAH, and substances produced during hemolysis of subarachnoid blood clots are believed to be responsible for stimulating the production of ET-1. The biosynthesis of ET-1 is a multi-step process, involving the conversion of the relatively inactive precursor big ET-1 to the mature peptide by endothelin converting enzyme (ECE), a metalloprotease. Consequently, ECE inhibitors are expected to suppress the biosynthesis of ET-1 and reduce the pathologic impact resulting from overproduction of this peptide. The purpose of the present study was to investigate the effects of an ECE inhibitor, CGS 26303, on hemolysate-induced injury of cerebral vessel endothelial cells as well as the production of ET-1 from these cells.lld:pubmed
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pubmed-article:12480208pubmed:authorpubmed-author:KassellNeal...lld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:LeeKevin SKSlld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:LinChih-LungC...lld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:KwanAij-LieALlld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:ChangChih-Zen...lld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:HowngShen-Lon...lld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:JengArco YAYlld:pubmed
pubmed-article:12480208pubmed:authorpubmed-author:WinardiDaniel...lld:pubmed
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pubmed-article:12480208pubmed:volume58lld:pubmed
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pubmed-article:12480208pubmed:pagination181-7; discussion 187-8lld:pubmed
pubmed-article:12480208pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:12480208pubmed:articleTitleAttenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor.lld:pubmed
pubmed-article:12480208pubmed:affiliationDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China.lld:pubmed
pubmed-article:12480208pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12480208pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:12480208pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed