| pubmed-article:12479814 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12479814 | lifeskim:mentions | umls-concept:C0166417 | lld:lifeskim |
| pubmed-article:12479814 | lifeskim:mentions | umls-concept:C1333261 | lld:lifeskim |
| pubmed-article:12479814 | lifeskim:mentions | umls-concept:C1159884 | lld:lifeskim |
| pubmed-article:12479814 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:12479814 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12479814 | pubmed:dateCreated | 2002-12-13 | lld:pubmed |
| pubmed-article:12479814 | pubmed:abstractText | The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPARgamma's capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPARgamma-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPARgamma activity and adipocyte differentiation. | lld:pubmed |
| pubmed-article:12479814 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12479814 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12479814 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12479814 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12479814 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12479814 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:AuwerxJohanJ | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:KristiansenKa... | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:FajasLluisL | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:ReiterRaphael... | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:EglerVivianeV | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:HansenJacobJ | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:DebrilMarie-B... | lld:pubmed |
| pubmed-article:12479814 | pubmed:author | pubmed-author:MiardStéphani... | lld:pubmed |
| pubmed-article:12479814 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12479814 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:12479814 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12479814 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12479814 | pubmed:pagination | 903-10 | lld:pubmed |
| pubmed-article:12479814 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12479814 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12479814 | pubmed:articleTitle | The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. | lld:pubmed |
| pubmed-article:12479814 | pubmed:affiliation | Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France. | lld:pubmed |
| pubmed-article:12479814 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12479814 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12479814 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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