| pubmed-article:12467705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12467705 | lifeskim:mentions | umls-concept:C0279516 | lld:lifeskim |
| pubmed-article:12467705 | lifeskim:mentions | umls-concept:C0887953 | lld:lifeskim |
| pubmed-article:12467705 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12467705 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12467705 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12467705 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12467705 | pubmed:dateCreated | 2002-12-6 | lld:pubmed |
| pubmed-article:12467705 | pubmed:abstractText | A series of 5-substituted oxazolidinones with varying substitution at the 5-position of the oxazolidinone ring were synthesized and their in vitro antibacterial activity was evaluated. The compounds demonstrated potent to weak antibacterial activity. A novel compound (PH-027) demonstrated potent antibacterial activity, which is comparable to or better than those of linezolid and vancomycin against antibiotic-susceptible standard and clinically isolated resistant strains of gram-positive bacteria. Although the presence of the C-5-acetamidomethyl functionality at the C-5 position of the oxazolidinones has been widely claimed and reported as a structural requirement for optimal antimicrobial activity in the oxazolidinone class of compounds, our results from this work identified the C-5 triazole substitution as a new structural alternative for potent antibacterial activity in the oxazolidinone class. | lld:pubmed |
| pubmed-article:12467705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12467705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12467705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12467705 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12467705 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:12467705 | pubmed:author | pubmed-author:UdoE EEE | lld:pubmed |
| pubmed-article:12467705 | pubmed:author | pubmed-author:PhillipsO AOA | lld:pubmed |
| pubmed-article:12467705 | pubmed:author | pubmed-author:AliA A MAA | lld:pubmed |
| pubmed-article:12467705 | pubmed:author | pubmed-author:Al-HassawiNN | lld:pubmed |
| pubmed-article:12467705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12467705 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:12467705 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:12467705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12467705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12467705 | pubmed:pagination | 35-41 | lld:pubmed |
| pubmed-article:12467705 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:meshHeading | pubmed-meshheading:12467705... | lld:pubmed |
| pubmed-article:12467705 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12467705 | pubmed:articleTitle | Synthesis and antibacterial activity of 5-substituted oxazolidinones. | lld:pubmed |
| pubmed-article:12467705 | pubmed:affiliation | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait. dphillips@hsc.kuniv.edu.kw | lld:pubmed |
| pubmed-article:12467705 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12467705 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12467705 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12467705 | lld:pubmed |
