| pubmed-article:12466296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C0752248 | lld:lifeskim |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:12466296 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:12466296 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12466296 | pubmed:dateCreated | 2002-12-5 | lld:pubmed |
| pubmed-article:12466296 | pubmed:abstractText | Large-scale gene expression profiling was performed on embryo-derived stem cell lines to identify molecular signatures of pluripotency and lineage specificity. Analysis of pluripotent embryonic stem (ES) cells, extraembryonic-restricted trophoblast stem (TS) cells, and terminally-differentiated mouse embryo fibroblast (MEF) cells identified expression profiles unique to each cell type, as well as genes common only to ES and TS cells. Whereas most of the MEF-specific genes had been characterized previously, the majority (67%) of the ES-specific genes were novel and did not include known differentiated cell markers. Comparison with microarray data from embryonic material demonstrated that ES-specific genes were underrepresented in all stages sampled, whereas TS-specific genes included known placental markers. Investigation of four novel TS-specific genes showed trophoblast-restricted expression in cell lines and in vivo, whereas one uncharacterized ES-specific gene, Esg-1, was found to be exclusively associated with pluripotency. We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage. | lld:pubmed |
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| pubmed-article:12466296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12466296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466296 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12466296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12466296 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12466296 | pubmed:issn | 1088-9051 | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:RossantJanetJ | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:NiwaHitoshiH | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:TanakaTetsuya... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:YokotaTakashi... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:JaradatSaied... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:KoMinoru S... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:KunathTiloT | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:KimberWendy... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:StaggCarole... | lld:pubmed |
| pubmed-article:12466296 | pubmed:author | pubmed-author:UsudaMasayuki... | lld:pubmed |
| pubmed-article:12466296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12466296 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12466296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12466296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12466296 | pubmed:pagination | 1921-8 | lld:pubmed |
| pubmed-article:12466296 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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