| pubmed-article:12466140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0011980 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12466140 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:12466140 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12466140 | pubmed:dateCreated | 2002-12-5 | lld:pubmed |
| pubmed-article:12466140 | pubmed:abstractText | Limited knowledge exists regarding the efficacy of insulin-like growth factor I (IGF-I) administration as a therapeutic intervention for muscular dystrophies, although findings from other muscle pathology models suggest clinical potential. The diaphragm muscles of mdx mice (a model for Duchenne muscular dystrophy) were examined after 8 weeks of IGF-I administration (1 mg/kg s.c.) to test the hypothesis that IGF-I would improve the functional properties of dystrophic skeletal muscles. Force per cross-sectional area was approximately 49% greater in the muscles of treated mdx mice (149.6 +/- 9.6 kN/m(2)) compared with untreated mice (100.1 +/- 4.6 kN/m(2), P < 0.05), and maintenance of force over repeated maximal contraction was enhanced approximately 30% in muscles of treated mice (P < 0.05). Diaphragm muscles from treated mice comprised fibers with approximately 36% elevated activity of the oxidative enzyme succinate dehydrogenase, and approximately 23% reduction in the proportion of fast IId/x muscle fibers with concomitant increase in the proportion of type IIa fibers compared with untreated mice (P < 0.05). The data demonstrate that IGF-I administration can enhance the fatigue resistance of respiratory muscles in an animal model of dystrophin deficiency, in conjunction with enhancing energenic enzyme activity. As respiratory function is a mortality predictor in Duchenne muscular dystrophy patients, further evaluation of IGF-I intervention is recommended. | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12466140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12466140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12466140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12466140 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12466140 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:12466140 | pubmed:author | pubmed-author:BachLeon ALA | lld:pubmed |
| pubmed-article:12466140 | pubmed:author | pubmed-author:GregorevicPau... | lld:pubmed |
| pubmed-article:12466140 | pubmed:author | pubmed-author:LynchGordon... | lld:pubmed |
| pubmed-article:12466140 | pubmed:author | pubmed-author:PlantDavid... | lld:pubmed |
| pubmed-article:12466140 | pubmed:author | pubmed-author:LeedingKerri... | lld:pubmed |
| pubmed-article:12466140 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12466140 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:12466140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12466140 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12466140 | pubmed:pagination | 2263-72 | lld:pubmed |
| pubmed-article:12466140 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:meshHeading | pubmed-meshheading:12466140... | lld:pubmed |
| pubmed-article:12466140 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12466140 | pubmed:articleTitle | Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration. | lld:pubmed |
| pubmed-article:12466140 | pubmed:affiliation | Department of Physiology, The University of Melbourne, Victoria, Australia 3010. | lld:pubmed |
| pubmed-article:12466140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12466140 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12466140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:12466140 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12466140 | lld:pubmed |
