| pubmed-article:12464454 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0002658 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0175405 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0456603 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0205329 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0205156 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0086960 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:12464454 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:12464454 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12464454 | pubmed:dateCreated | 2002-12-4 | lld:pubmed |
| pubmed-article:12464454 | pubmed:abstractText | The effect of previous exposure to amphetamine (AMPH) in the ventral tegmental area (VTA) on the subsequent self-administration of cocaine was assessed. Rats in different groups were pre-exposed to three injections into the VTA of either saline (0.5 microl/side) or AMPH (2.5 microg/0.5 microl/side). Injections were given once every third day. Starting 7-10 days after the last pre-exposure injection, rats were trained to self-administer cocaine (0.3 mg/kg/infusion) under fixed ratio 1 and 2 (FR1 and FR2) schedules and then tested under a progressive ratio (PR) schedule of reinforcement for six consecutive days. No differences between groups were observed during self-administration training under the FR schedules of reinforcement. However, when tested under the PR schedule, VTA AMPH pre-exposed rats worked more and, as a result, obtained more infusions of cocaine than saline pre-exposed rats. Rats in a separate group pre-exposed to VTA AMPH but co-infused with the D(1)-like dopamine (DA) receptor antagonist SCH23390 (0.25 microg/0.5 microl/side) did not show enhanced cocaine self-administration. These rats, as well as others pre-exposed to VTA SCH23390 alone showed levels of cocaine self-administration similar to saline pre-exposed rats. Thus, in a manner paralleling the sensitization of AMPH-induced locomotion and nucleus accumbens DA overflow, previous exposure to AMPH in the VTA leads to enhanced intravenous self-administration of cocaine and activation of D(1) DA receptors in this site during pre-exposure is necessary for the production of this effect. | lld:pubmed |
| pubmed-article:12464454 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12464454 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12464454 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12464454 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12464454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12464454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12464454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12464454 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12464454 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12464454 | pubmed:issn | 0893-133X | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:WrightD ADA | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:VezinaPP | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:SutoNN | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:KramerM KMK | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:AustinJ DJD | lld:pubmed |
| pubmed-article:12464454 | pubmed:author | pubmed-author:TanabeL MLM | lld:pubmed |
| pubmed-article:12464454 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12464454 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:12464454 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12464454 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12464454 | pubmed:pagination | 970-9 | lld:pubmed |
| pubmed-article:12464454 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:meshHeading | pubmed-meshheading:12464454... | lld:pubmed |
| pubmed-article:12464454 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12464454 | pubmed:articleTitle | Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. | lld:pubmed |
| pubmed-article:12464454 | pubmed:affiliation | Department of Psychology, The University of Chicago, Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:12464454 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12464454 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12464454 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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